Penicillin and Aseptic necrosis - a phase IV clinical study of FDA data

Summary:

Aseptic necrosis is reported as a side effect among people who take Penicillin (penicillin g potassium), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Truvada, and have Hiv infection.

The phase IV clinical study analyzes which people have Aseptic necrosis when taking Penicillin. It is created by eHealthMe based on reports of 7,964 people who have side effects when taking Penicillin from the FDA, and is updated regularly.

What is Penicillin?

Penicillin has active ingredients of penicillin g potassium. It is often used in strep throat. eHealthMe is studying from 8,567 Penicillin users. Check the latest studies of Penicillin.

What is Aseptic necrosis?

Aseptic necrosis (the death of bone tissue due to a lack of blood supply) is found to be associated with 1,348 drugs and 1,692 conditions by eHealthMe. Check the latest studies of Aseptic necrosis.

On Jul, 15, 2026

7,964 people reported to have side effects when taking Penicillin.
Among them, 39 people (0.49%) have Aseptic necrosis.

Could Penicillin cause Aseptic necrosis?

Among these 39 people:

How long have people been on Penicillin when they have Aseptic necrosis? *

What is the gender of people who have Aseptic necrosis when taking Penicillin? *

female: 35.14 %
male: 64.86 %

What is the age of people who have Aseptic necrosis when taking Penicillin? *

What are other drugs people take besides Penicillin? *

What are other side effects people have besides Aseptic necrosis? *

Pain: 32 people, 82.05%
Emotional Distress: 23 people, 58.97%
Bone Loss: 22 people, 56.41%
Stress And Anxiety: 21 people, 53.85%
Bone Density Decreased: 19 people, 48.72%
Tooth Loss: 14 people, 35.90%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 13 people, 33.33%
Acute Kidney Failure: 13 people, 33.33%
Chronic Kidney Disease: 13 people, 33.33%
Depression: 12 people, 30.77%

What are the existing conditions these people have? *

Hiv Infection: 24 people, 61.54%
Pain: 5 people, 12.82%
Cough: 3 people, 7.69%
Multiple Myeloma (cancer of the plasma cells): 3 people, 7.69%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 2 people, 5.13%
Metastases To Bone (cancer spreads to bone): 2 people, 5.13%
High Blood Pressure: 2 people, 5.13%
Stress And Anxiety: 2 people, 5.13%
Irritable Bowel Syndrome: 2 people, 5.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Penicillin and have Aseptic necrosis?

- Check whether Aseptic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Penicillin:

Penicillin (8,567 reports)

Aseptic necrosis treatments and more:

Aseptic necrosis (59,829 reports)

Browse all side effects of Penicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aseptic necrosis:

Aseptic necrosis (1,348 drugs)

Browse all the conditions that are associated with Aseptic necrosis:

Aseptic necrosis (1,692 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on penicillin g potassium (the active ingredients of Penicillin) and Penicillin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.