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Penicillin and Interstitial nephritis - a phase IV clinical study of FDA data

Summary:

Interstitial nephritis is reported as a side effect among people who take Penicillin (penicillin g potassium), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Nexium, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Interstitial nephritis when taking Penicillin. It is created by eHealthMe based on reports of 7,964 people who have side effects when taking Penicillin from the FDA, and is updated regularly.

What is Penicillin?

Penicillin has active ingredients of penicillin g potassium. It is often used in strep throat. eHealthMe is studying from 8,567 Penicillin users. Check the latest studies of Penicillin.

What is Interstitial nephritis?

Interstitial nephritis (inflammation of the kidney) is found to be associated with 1,090 drugs and 1,567 conditions by eHealthMe. Check the latest studies of Interstitial nephritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

7,964 people reported to have side effects when taking Penicillin.
Among them, 82 people (1.03%) have Interstitial nephritis.

Could Penicillin cause Interstitial nephritis?

Among these 82 people:

How long have people been on Penicillin when they have Interstitial nephritis? *

  • < 1 month: 41.67 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 8.33 %
  • 1 - 2 years: 25.0 %
  • 2 - 5 years: 25.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Interstitial nephritis when taking Penicillin? *

  • female: 55.13 %
  • male: 44.87 %

What is the age of people who have Interstitial nephritis when taking Penicillin? *

  • 0-1: 2.78 %
  • 2-9: 12.5 %
  • 10-19: 6.94 %
  • 20-29: 6.94 %
  • 30-39: 11.11 %
  • 40-49: 15.28 %
  • 50-59: 29.17 %
  • 60+: 15.28 %

What are other drugs people take besides Penicillin? *

  1. Nexium: 46 people, 56.10%
  2. Prilosec: 40 people, 48.78%
  3. Prevacid: 33 people, 40.24%
  4. Protonix: 30 people, 36.59%
  5. Prilosec Otc: 29 people, 35.37%
  6. Vancomycin: 20 people, 24.39%
  7. Nexium 24hr: 19 people, 23.17%
  8. Pantoprazole: 18 people, 21.95%
  9. Acyclovir: 17 people, 20.73%
  10. Prevacid 24 Hr: 16 people, 19.51%

What are other side effects people have besides Interstitial nephritis? *

  1. Chronic Kidney Disease: 55 people, 67.07%
  2. Acute Kidney Failure: 34 people, 41.46%
  3. Renal Injury (kidney injury): 15 people, 18.29%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 17.07%
  5. Renal Tubular Necrosis (death of kidney tubules): 10 people, 12.20%
  6. Mesangioproliferative Glomerulonephritis (an inflammatory disease of both kidneys): 8 people, 9.76%
  7. Nephrogenic Anaemia (anaemia due to kidney disease): 8 people, 9.76%
  8. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue): 7 people, 8.54%
  9. Focal Segmental Glomerulosclerosis (scar tissue that forms in parts of the kidney called glomeruli): 6 people, 7.32%
  10. Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 4 people, 4.88%

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 52 people, 63.41%
  2. Pain: 39 people, 47.56%
  3. High Blood Pressure: 25 people, 30.49%
  4. High Blood Cholesterol: 23 people, 28.05%
  5. Bone Marrow Conditioning Regimen: 14 people, 17.07%
  6. Stress And Anxiety: 13 people, 15.85%
  7. Hyperlipidaemia (presence of excess lipids in the blood): 10 people, 12.20%
  8. Depression: 10 people, 12.20%
  9. Aplastic Anemia: 7 people, 8.54%
  10. Headache (pain in head): 6 people, 7.32%

* Approximation only. Some reports may have incomplete information.

Do you take Penicillin and have Interstitial nephritis?

- Check whether Interstitial nephritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Penicillin:

Interstitial nephritis treatments and more:

How severe was Interstitial nephritis and when was it recovered:

Expand to all the drugs that have ingredients of penicillin g potassium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Penicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Interstitial nephritis:

Browse all the conditions that are associated with Interstitial nephritis:

How the study uses the data?

The study uses data from the FDA. It is based on penicillin g potassium (the active ingredients of Penicillin) and Penicillin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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