Pennsaid and Application site dryness - a phase IV clinical study of FDA data

Summary:

Application site dryness is reported as a side effect among people who take Pennsaid (diclofenac sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Allegra, and have Joint pain.

The phase IV clinical study analyzes which people have Application site dryness when taking Pennsaid. It is created by eHealthMe based on reports of 2,824 people who have side effects when taking Pennsaid from the FDA, and is updated regularly.

What is Pennsaid?

Pennsaid has active ingredients of diclofenac sodium. eHealthMe is studying from 2,849 Pennsaid users. Check the latest studies of Pennsaid.

What is Application site dryness?

Application site dryness is found to be associated with 125 drugs and 310 conditions by eHealthMe. Check the latest studies of Application site dryness.

On Jul, 19, 2026

2,824 people reported to have side effects when taking Pennsaid.
Among them, 27 people (0.96%) have Application site dryness.

Could Pennsaid cause Application site dryness?

Among these 27 people:

How long have people been on Pennsaid when they have Application site dryness? *

What is the gender of people who have Application site dryness when taking Pennsaid? *

female: 70.37 %
male: 29.63 %

What is the age of people who have Application site dryness when taking Pennsaid? *

What are other drugs people take besides Pennsaid? *

What are other side effects people have besides Application site dryness? *

Application Site Exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface): 14 people, 51.85%
Application Site Pruritus (application site severe itching of the skin): 9 people, 33.33%
Application Site Erythema (redness of the skin at application site): 8 people, 29.63%
Application Site Rash: 3 people, 11.11%
Application Site Pain: 3 people, 11.11%
Skin Exfoliation (removal of the oldest dead skin cells): 2 people, 7.41%
Application Site Discoloration: 2 people, 7.41%
Application Site Swelling: 2 people, 7.41%
Application Site Paraesthesia (abnormal skin sensation of tingling, tickling, prickling, pricking, or burning felt at application site): 1 person, 3.70%
Application Site Inflammation: 1 person, 3.70%

What are the existing conditions these people have? *

Joint Pain: 5 people, 18.52%
Pain In Extremity: 4 people, 14.81%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 14.81%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 7.41%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 7.41%
Tenosynovitis Stenosans (a common disorder characterized by catching, snapping or locking of the involved finger flexor tendon, associated with dysfunction and pain): 1 person, 3.70%
Tendonitis (a condition that causes pain and swelling of tendons): 1 person, 3.70%
Tendon Rupture (tear of tendon): 1 person, 3.70%
Neck Pain: 1 person, 3.70%
Exostosis (formation of new bone on the surface of a bone): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Pennsaid and have Application site dryness?

- Check whether Application site dryness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pennsaid:

Pennsaid (2,849 reports)

Browse all side effects of Pennsaid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site dryness:

Application site dryness (125 drugs)

Browse all the conditions that are associated with Application site dryness:

Application site dryness (310 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diclofenac sodium (the active ingredients of Pennsaid) and Pennsaid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.