Pentam and Diastolic dysfunction - a phase IV clinical study of FDA data

Summary:

Diastolic dysfunction is reported as a side effect among people who take Pentam (pentamidine isethionate), especially for people who are male, 60+ old, also take Ondansetron, and have Bone marrow conditioning regimen.

The phase IV clinical study analyzes which people have Diastolic dysfunction when taking Pentam. It is created by eHealthMe based on reports of 5,677 people who have side effects when taking Pentam from the FDA, and is updated regularly.

What is Pentam?

Pentam has active ingredients of pentamidine isethionate. eHealthMe is studying from 5,686 Pentam users. Check the latest studies of Pentam.

What is Diastolic dysfunction?

Diastolic dysfunction is found to be associated with 677 drugs and 631 conditions by eHealthMe. Check the latest studies of Diastolic dysfunction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

5,677 people reported to have side effects when taking Pentam.
Among them, 12 people (0.21%) have Diastolic dysfunction.

Could Pentam cause Diastolic dysfunction?

Among these 12 people:

What is the gender of people who have Diastolic dysfunction when taking Pentam? *

female: 0.0 %
male: 100 %

What is the age of people who have Diastolic dysfunction when taking Pentam? *

What are other drugs people take besides Pentam? *

What are other side effects people have besides Diastolic dysfunction? *

Ventricular Hypokinesia (muscle of one's heart does not contract as much as most peoples' hearts do): 9 people, 75.00%
Atelectasis (partial or complete collapse of the lung): 9 people, 75.00%
Staphylococcal Infection (an infection with staphylococcus bacteria): 9 people, 75.00%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 9 people, 75.00%
Renal Impairment (severely reduced kidney function): 9 people, 75.00%
Pulmonary Oedema (fluid accumulation in the lungs): 9 people, 75.00%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 9 people, 75.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 9 people, 75.00%
Pleural Effusion (water on the lungs): 9 people, 75.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 75.00%

What are the existing conditions these people have? *

Bone Marrow Conditioning Regimen: 9 people, 75.00%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Pentam and have Diastolic dysfunction?

- Check whether Diastolic dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pentam:

Pentam (5,686 reports)

Browse all side effects of Pentam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diastolic dysfunction:

Diastolic dysfunction (677 drugs)

Browse all the conditions that are associated with Diastolic dysfunction:

Diastolic dysfunction (631 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pentamidine isethionate (the active ingredients of Pentam) and Pentam (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.