Pepcid and Aortic stenosis - a phase IV clinical study of FDA data

Summary:

Aortic stenosis is reported as a side effect among people who take Pepcid (famotidine), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Aspirin, and have Joint pain.

The phase IV clinical study analyzes which people have Aortic stenosis when taking Pepcid. It is created by eHealthMe based on reports of 54,527 people who have side effects when taking Pepcid from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,775 Pepcid users. Check the latest studies of Pepcid.

What is Aortic stenosis?

Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta) is found to be associated with 779 drugs and 972 conditions by eHealthMe. Check the latest studies of Aortic stenosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

54,527 people reported to have side effects when taking Pepcid.
Among them, 90 people (0.17%) have Aortic stenosis.

Among these 90 people:

How long have people been on Pepcid when they have Aortic stenosis? *

What is the gender of people who have Aortic stenosis when taking Pepcid? *

female: 43.82 %
male: 56.18 %

What is the age of people who have Aortic stenosis when taking Pepcid? *

What are other drugs people take besides Pepcid? *

What are other side effects people have besides Aortic stenosis? *

Cardiac Failure Congestive: 44 people, 48.89%
Mitral Valve Incompetence (inefficient heart valve): 40 people, 44.44%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 36 people, 40.00%
Fainting (loss of consciousness and postural tone): 32 people, 35.56%
High Blood Pressure: 31 people, 34.44%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 30 people, 33.33%
Stress And Anxiety: 29 people, 32.22%
Anaemia (lack of blood): 29 people, 32.22%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 28 people, 31.11%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 28 people, 31.11%

What are the existing conditions these people have? *

Joint Pain: 11 people, 12.22%
High Blood Pressure: 7 people, 7.78%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 7.78%
Multiple Myeloma (cancer of the plasma cells): 6 people, 6.67%
Depression: 5 people, 5.56%
Lipids Abnormal: 4 people, 4.44%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 3.33%
Back Disorder: 3 people, 3.33%
Back Pain: 3 people, 3.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Pepcid and have Aortic stenosis?

- Check whether Aortic stenosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pepcid:

Pepcid (55,775 reports)

Aortic stenosis treatments and more:

Aortic stenosis (8,138 reports)

Browse all side effects of Pepcid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic stenosis:

Aortic stenosis (779 drugs)

Browse all the conditions that are associated with Aortic stenosis:

Aortic stenosis (972 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on famotidine (the active ingredients of Pepcid) and Pepcid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.