Pepcid and Hyperaesthesia - a phase IV clinical study of FDA data

Summary:

Hyperaesthesia is reported as a side effect among people who take Pepcid (famotidine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Synthroid, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Hyperaesthesia when taking Pepcid. It is created by eHealthMe based on reports of 54,527 people who have side effects when taking Pepcid from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,770 Pepcid users. Check the latest studies of Pepcid.

What is Hyperaesthesia?

Hyperaesthesia is found to be associated with 912 drugs and 909 conditions by eHealthMe. Check the latest studies of Hyperaesthesia.

On Jan, 21, 2026

54,527 people reported to have side effects when taking Pepcid.
Among them, 44 people (0.08%) have Hyperaesthesia.

Among these 44 people:

How long have people been on Pepcid when they have Hyperaesthesia? *

What is the gender of people who have Hyperaesthesia when taking Pepcid? *

female: 65.91 %
male: 34.09 %

What is the age of people who have Hyperaesthesia when taking Pepcid? *

What are other drugs people take besides Pepcid? *

What are other side effects people have besides Hyperaesthesia? *

Pain: 12 people, 27.27%
Fatigue (feeling of tiredness): 11 people, 25.00%
Joint Pain: 8 people, 18.18%
Rashes (redness): 8 people, 18.18%
Diarrhea: 8 people, 18.18%
Nausea (feeling of having an urge to vomit): 7 people, 15.91%
Itching: 6 people, 13.64%
Hypoaesthesia (reduced sense of touch or sensation): 6 people, 13.64%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 13.64%
Stress And Anxiety: 6 people, 13.64%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 11.36%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 6.82%
Depression: 3 people, 6.82%
Breast Cancer Metastatic: 2 people, 4.55%
Pain: 2 people, 4.55%
Nausea (feeling of having an urge to vomit): 2 people, 4.55%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 4.55%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 4.55%
Multiple Myeloma (cancer of the plasma cells): 2 people, 4.55%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Pepcid and have Hyperaesthesia?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pepcid:

Pepcid (55,770 reports)

Hyperaesthesia treatments and more:

Hyperaesthesia (10,827 reports)

Browse all side effects of Pepcid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperaesthesia:

Hyperaesthesia (912 drugs)

Browse all the conditions that are associated with Hyperaesthesia:

Hyperaesthesia (909 conditions)

Drugs similar to Pepcid and Hyperaesthesia :

How the study uses the data?

The study uses data from the FDA. It is based on famotidine (the active ingredients of Pepcid) and Pepcid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.