Pepcid and Systemic sclerosis (scleroderma) - a phase IV clinical study of FDA data

Summary:

Systemic sclerosis (scleroderma) is reported as a side effect among people who take Pepcid (famotidine), especially for people who are female, 50-59 old, also take Potassium, and have Pulmonary hypertension.

The phase IV clinical study analyzes which people have Systemic sclerosis (scleroderma) when taking Pepcid. It is created by eHealthMe based on reports of 54,527 people who have side effects when taking Pepcid from the FDA, and is updated regularly.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

What is Systemic sclerosis (scleroderma)?

Systemic sclerosis (scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin) is found to be associated with 495 drugs and 857 conditions by eHealthMe. Check the latest studies of Systemic sclerosis (scleroderma).

On Jul, 13, 2026

54,527 people reported to have side effects when taking Pepcid.
Among them, 19 people (0.03%) have Systemic sclerosis (scleroderma).

Could Pepcid cause Systemic sclerosis (scleroderma)?

Among these 19 people:

What is the gender of people who have Systemic sclerosis (scleroderma) when taking Pepcid? *

female: 73.68 %
male: 26.32 %

What is the age of people who have Systemic sclerosis (scleroderma) when taking Pepcid? *

What are other drugs people take besides Pepcid? *

What are other side effects people have besides Systemic sclerosis (scleroderma)? *

Cardiac Arrest: 4 people, 21.05%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 4 people, 21.05%
Melaena (the passage of black, tarry stools): 4 people, 21.05%
Cardiac Failure Congestive: 4 people, 21.05%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 3 people, 15.79%
Pneumonitis Aspiration (acute lung injury after the inhalation of regurgitated gastric contents): 3 people, 15.79%
Gastric Mucosal Lesion (lesion of stomach mucous membrane): 3 people, 15.79%
Diarrhea: 3 people, 15.79%
Pericardial Effusion (fluid around the heart): 3 people, 15.79%
Hypotension (abnormally low blood pressure): 3 people, 15.79%

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 21.05%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 15.79%
Thyroid Diseases: 1 person, 5.26%
Stress And Anxiety: 1 person, 5.26%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.26%
Panic Disorder: 1 person, 5.26%
Nausea (feeling of having an urge to vomit): 1 person, 5.26%
Lung Disorder (lung disease): 1 person, 5.26%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 1 person, 5.26%
Hypersensitivity: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Pepcid and have Systemic sclerosis (scleroderma)?

- Check whether Systemic sclerosis (scleroderma) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pepcid:

Pepcid (55,774 reports)

Browse all side effects of Pepcid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (495 drugs)

Browse all the conditions that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (857 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on famotidine (the active ingredients of Pepcid) and Pepcid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.