Peppermint and Agranulocytosis - a phase IV clinical study of FDA data

Summary:

Agranulocytosis is reported as a side effect among people who take Peppermint (peppermint), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Valacyclovir Hydrochloride, and have Depression.

The phase IV clinical study analyzes which people have Agranulocytosis when taking Peppermint. It is created by eHealthMe based on reports of 1,289 people who have side effects when taking Peppermint from the FDA, and is updated regularly.

What is Peppermint?

Peppermint has active ingredients of peppermint. eHealthMe is studying from 1,327 Peppermint users. Check the latest studies of Peppermint.

What is Agranulocytosis?

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection) is found to be associated with 2,321 drugs and 3,597 conditions by eHealthMe. Check the latest studies of Agranulocytosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

1,289 people reported to have side effects when taking Peppermint.
Among them, 24 people (1.86%) have Agranulocytosis.

Among these 24 people:

How long have people been on Peppermint when they have Agranulocytosis? *

What is the gender of people who have Agranulocytosis when taking Peppermint? *

female: 86.96 %
male: 13.04 %

What is the age of people who have Agranulocytosis when taking Peppermint? *

What are other drugs people take besides Peppermint? *

Valacyclovir Hydrochloride: 15 people, 62.50%
Bendamustine: 10 people, 41.67%
Escitalopram: 10 people, 41.67%
Alprazolam: 10 people, 41.67%
Atovaquone: 10 people, 41.67%
Revlimid: 7 people, 29.17%
Eucalyptus Oil: 6 people, 25.00%
Dexamethasone: 6 people, 25.00%
Topiramate: 5 people, 20.83%
Lansoprazole: 5 people, 20.83%

What are other side effects people have besides Agranulocytosis? *

Diarrhea: 7 people, 29.17%
Fatigue (feeling of tiredness): 6 people, 25.00%
Headache (pain in head): 6 people, 25.00%
Upper Respiratory Tract Infection: 5 people, 20.83%
Dizziness: 5 people, 20.83%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 5 people, 20.83%
Rashes (redness): 5 people, 20.83%
Nausea (feeling of having an urge to vomit): 5 people, 20.83%
Insomnia (sleeplessness): 5 people, 20.83%
Itching: 5 people, 20.83%

What are the existing conditions these people have? *

Depression: 11 people, 45.83%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 10 people, 41.67%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 10 people, 41.67%
Multiple Myeloma (cancer of the plasma cells): 8 people, 33.33%
Upper Respiratory Tract Infection: 5 people, 20.83%
Light Chain Disease (a rare blood cell disease which is characterized by deposition of fragments of infection-fighting immunoglobulins): 2 people, 8.33%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 8.33%
Skin Infection: 1 person, 4.17%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 4.17%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Peppermint and have Agranulocytosis?

- Check whether Agranulocytosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Peppermint:

Peppermint (1,327 reports)

Agranulocytosis treatments and more:

Agranulocytosis (213,267 reports)

Browse all side effects of Peppermint:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agranulocytosis:

Agranulocytosis (2,321 drugs)

Browse all the conditions that are associated with Agranulocytosis:

Agranulocytosis (3,597 conditions)

Related publications that referenced our studies

Fasullo, S., Davì, S., Cosenza, G., Di Franco, F., La Manna, N., Giubilato, A., ... & Maringhini, G. , "Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature", Journal of thrombosis and thrombolysis, 2018 Jan .
Fasullo, S., Davì, S., Cosenza, G., Di Franco, F., La Manna, N., Giubilato, A., ... & Maringhini, G. , "Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature", Journal of thrombosis and thrombolysis, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on peppermint (the active ingredients of Peppermint) and Peppermint (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.