Percocet and Acute hepatic failure - a phase IV clinical study of FDA data

Summary:

Acute hepatic failure is reported as a side effect among people who take Percocet (acetaminophen; oxycodone hydrochloride), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Tylenol, and have Ill-defined disorder.

The phase IV clinical study analyzes which people have Acute hepatic failure when taking Percocet. It is created by eHealthMe based on reports of 116,194 people who have side effects when taking Percocet from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Acute hepatic failure?

Acute hepatic failure is found to be associated with 710 drugs and 1,180 conditions by eHealthMe. Check the latest studies of Acute hepatic failure.

On Jul, 05, 2026

116,194 people reported to have side effects when taking Percocet.
Among them, 48 people (0.04%) have Acute hepatic failure.

Could Percocet cause Acute hepatic failure?

Among these 48 people:

How long have people been on Percocet when they have Acute hepatic failure? *

What is the gender of people who have Acute hepatic failure when taking Percocet? *

female: 78.72 %
male: 21.28 %

What is the age of people who have Acute hepatic failure when taking Percocet? *

What are other drugs people take besides Percocet? *

What are other side effects people have besides Acute hepatic failure? *

Overdose: 18 people, 37.50%
Drug Administration Error: 11 people, 22.92%
Acute Kidney Failure: 11 people, 22.92%
Consciousness - Decreased: 6 people, 12.50%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 5 people, 10.42%
Hypotension (abnormally low blood pressure): 5 people, 10.42%
Bleeding Disorders: 5 people, 10.42%
Encephalopathy (functioning of the brain is affected by some agent or condition): 4 people, 8.33%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 4 people, 8.33%
Anaemia (lack of blood): 4 people, 8.33%

What are the existing conditions these people have? *

Ill-Defined Disorder: 7 people, 14.58%
Headache (pain in head): 6 people, 12.50%
Depression: 3 people, 6.25%
Migraine (headache): 3 people, 6.25%
Stress And Anxiety: 3 people, 6.25%
Sleep Disorder: 3 people, 6.25%
Nausea (feeling of having an urge to vomit): 3 people, 6.25%
Fever: 3 people, 6.25%
Joint Pain: 2 people, 4.17%
Itching: 2 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Percocet and have Acute hepatic failure?

- Check whether Acute hepatic failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Percocet:

Percocet (119,838 reports)

Acute hepatic failure treatments and more:

Acute hepatic failure (13,839 reports)

How severe was Acute hepatic failure and when was it recovered:

Acute hepatic failure in Percocet

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Acute hepatic failure and drugs with ingredients of acetaminophen; oxycodone hydrochloride (91 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Percocet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute hepatic failure:

Acute hepatic failure (710 drugs)

Browse all the conditions that are associated with Acute hepatic failure:

Acute hepatic failure (1,180 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Percocet) and Percocet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.