Percocet and Polysubstance abuse - a phase IV clinical study of FDA data

Summary:

Polysubstance abuse is reported as a side effect among people who take Percocet (acetaminophen; oxycodone hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for 2 - 5 years also take Oxycontin, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Polysubstance abuse when taking Percocet. It is created by eHealthMe based on reports of 116,194 people who have side effects when taking Percocet from the FDA, and is updated regularly.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 119,838 Percocet users. Check the latest studies of Percocet.

What is Polysubstance abuse?

Polysubstance abuse is found to be associated with 90 drugs and 66 conditions by eHealthMe. Check the latest studies of Polysubstance abuse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

116,194 people reported to have side effects when taking Percocet.
Among them, 101 people (0.09%) have Polysubstance abuse.

Could Percocet cause Polysubstance abuse?

Among these 101 people:

How long have people been on Percocet when they have Polysubstance abuse? *

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What is the gender of people who have Polysubstance abuse when taking Percocet? *

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* Approximation only. Some reports may have incomplete information.

Do you take Percocet and have Polysubstance abuse?

- Check whether Polysubstance abuse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Percocet:

Percocet (119,838 reports)

Polysubstance abuse treatments and more:

Polysubstance abuse (861 reports)

How severe was Polysubstance abuse and when was it recovered:

Polysubstance abuse in Percocet

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Polysubstance abuse and drugs with ingredients of acetaminophen; oxycodone hydrochloride (116 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Percocet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polysubstance abuse:

Polysubstance abuse (90 drugs)

Browse all the conditions that are associated with Polysubstance abuse:

Polysubstance abuse (66 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Percocet) and Percocet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.