Percodan and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Percodan (aspirin; oxycodone hydrochloride; oxycodone terephthalate), especially for people who are female, 50-59 old, also take Paxil, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Headache when taking Percodan. It is created by eHealthMe based on reports of 12,849 people who have side effects when taking Percodan from the FDA, and is updated regularly.

What is Percodan?

Percodan has active ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate. It is often used in pain. eHealthMe is studying from 12,885 Percodan users. Check the latest studies of Percodan.

What is Headache?

Headache (pain in head) is found to be associated with 3,746 drugs and 5,764 conditions by eHealthMe. Check the latest studies of Headache.

On Jun, 14, 2026

12,849 people reported to have side effects when taking Percodan.
Among them, 58 people (0.45%) have Headache.

Among these 58 people:

What is the gender of people who have Headache when taking Percodan? *

female: 56.9 %
male: 43.1 %

What is the age of people who have Headache when taking Percodan? *

What are other drugs people take besides Percodan? *

What are other side effects people have besides Headache? *

Chest Pain: 22 people, 37.93%
Weakness: 21 people, 36.21%
Depression: 21 people, 36.21%
Stress And Anxiety: 19 people, 32.76%
Fatigue (feeling of tiredness): 19 people, 32.76%
Weight Decreased: 17 people, 29.31%
Fever: 16 people, 27.59%
Nausea (feeling of having an urge to vomit): 16 people, 27.59%
Dyspnea (difficult or laboured breathing): 15 people, 25.86%
Insomnia (sleeplessness): 14 people, 24.14%

What are the existing conditions these people have? *

Neuralgia (pain in one or more nerves): 5 people, 8.62%
Hyperthyroidism (over activity of the thyroid gland): 5 people, 8.62%
High Blood Cholesterol: 5 people, 8.62%
Osteoporosis (bones weak and more likely to break): 4 people, 6.90%
Depression: 4 people, 6.90%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 5.17%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 5.17%
Hiv Infection: 2 people, 3.45%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 1.72%
Quit Smoking: 1 person, 1.72%

* Approximation only. Some reports may have incomplete information.

Do you take Percodan and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Percodan:

Percodan (12,885 reports)

Headache treatments and more:

Headache (756,641 reports)

How severe was Headache and when was it recovered:

Headache in Percodan

Expand to all the drugs that have ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate:

Headache and drugs with ingredients of aspirin; oxycodone hydrochloride; oxycodone terephthalate (1,690 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Percodan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,746 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,764 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on aspirin; oxycodone hydrochloride; oxycodone terephthalate (the active ingredients of Percodan) and Percodan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.