Periogard and Excessive granulation tissue - a phase IV clinical study of FDA data

Summary:

Excessive granulation tissue is reported as a side effect among people who take Periogard (chlorhexidine gluconate), especially for people who are female, 50-59 old, also take Hytrin, and have Fatigue.

The phase IV clinical study analyzes which people have Excessive granulation tissue when taking Periogard. It is created by eHealthMe based on reports of 3,812 people who have side effects when taking Periogard from the FDA, and is updated regularly.

What is Periogard?

Periogard has active ingredients of chlorhexidine gluconate. eHealthMe is studying from 3,814 Periogard users. Check the latest studies of Periogard.

What is Excessive granulation tissue?

Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury) is found to be associated with 389 drugs and 286 conditions by eHealthMe. Check the latest studies of Excessive granulation tissue.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

3,812 people reported to have side effects when taking Periogard.
Among them, 14 people (0.37%) have Excessive granulation tissue.

Could Periogard cause Excessive granulation tissue?

Among these 14 people:

What is the gender of people who have Excessive granulation tissue when taking Periogard? *

female: 100 %
male: 0.0 %

What is the age of people who have Excessive granulation tissue when taking Periogard? *

What are other drugs people take besides Periogard? *

What are other side effects people have besides Excessive granulation tissue? *

Hypovolaemia (a decreased volume of circulating blood in the body): 14 people, 100.00%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 14 people, 100.00%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 14 people, 100.00%
Eczema Asteatotic (severe dry skin- during the winter months and in the elderly): 14 people, 100.00%
Emotional Distress: 14 people, 100.00%
Fall: 14 people, 100.00%
Fever: 14 people, 100.00%
Fibrous Histiocytoma (non cancer fibrous skin lesion): 14 people, 100.00%
Fluid Overload (too much fluid in the blood): 14 people, 100.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 100.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 100.00%
High Blood Pressure: 14 people, 100.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 100.00%
Fatigue (feeling of tiredness): 14 people, 100.00%

* Approximation only. Some reports may have incomplete information.

Do you take Periogard and have Excessive granulation tissue?

- Check whether Excessive granulation tissue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Periogard:

Periogard (3,814 reports)

Browse all side effects of Periogard:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Excessive granulation tissue:

Excessive granulation tissue (389 drugs)

Browse all the conditions that are associated with Excessive granulation tissue:

Excessive granulation tissue (286 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on chlorhexidine gluconate (the active ingredients of Periogard) and Periogard (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.