Periostat and Osteolysis - a phase IV clinical study of FDA data

Summary:

Osteolysis is reported as a side effect among people who take Periostat (doxycycline hyclate), especially for people who are female, 60+ old, also take Lorazepam, and have Breast cancer metastatic.

The phase IV clinical study analyzes which people have Osteolysis when taking Periostat. It is created by eHealthMe based on reports of 263 people who have side effects when taking Periostat from the FDA, and is updated regularly.

What is Periostat?

Periostat has active ingredients of doxycycline hyclate. eHealthMe is studying from 273 Periostat users. Check the latest studies of Periostat.

What is Osteolysis?

Osteolysis (dissolution of bone) is found to be associated with 689 drugs and 407 conditions by eHealthMe. Check the latest studies of Osteolysis.

On Jul, 16, 2026

263 people reported to have side effects when taking Periostat.
Among them, 16 people (6.08%) have Osteolysis.

Among these 16 people:

What is the gender of people who have Osteolysis when taking Periostat? *

female: 93.75 %
male: 6.25 %

What is the age of people who have Osteolysis when taking Periostat? *

What are other drugs people take besides Periostat? *

What are other side effects people have besides Osteolysis? *

Weight Decreased: 16 people, 100.00%
Joint Pain: 16 people, 100.00%
Oesophageal Obstruction (blockage of oesophagus): 16 people, 100.00%
Oesophageal Food Impaction (blockage of oesophagus by food): 16 people, 100.00%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 16 people, 100.00%
Mediastinal Mass (mass in the part of the chest that separates the lungs): 16 people, 100.00%
Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 16 people, 100.00%
Lymphoma (cancer that begins in immune system cells): 16 people, 100.00%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 16 people, 100.00%
Visual Impairment: 16 people, 100.00%

What are the existing conditions these people have? *

Breast Cancer Metastatic: 16 people, 100.00%
Gastroesophageal Cancer: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Periostat and have Osteolysis?

- Check whether Osteolysis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Periostat:

Periostat (273 reports)

Osteolysis treatments and more:

Osteolysis (4,092 reports)

Browse all side effects of Periostat:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteolysis:

Osteolysis (689 drugs)

Browse all the conditions that are associated with Osteolysis:

Osteolysis (407 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Periostat) and Periostat (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.