Phenergan and Sinus polyp degeneration - a phase IV clinical study of FDA data

Summary:

Sinus polyp degeneration is reported as a side effect among people who take Phenergan (promethazine hydrochloride), especially for people who are female, 40-49 old, also take Fareston, and have Diabetes.

The phase IV clinical study analyzes which people have Sinus polyp degeneration when taking Phenergan. It is created by eHealthMe based on reports of 24,254 people who have side effects when taking Phenergan from the FDA, and is updated regularly.

What is Phenergan?

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 25,312 Phenergan users. Check the latest studies of Phenergan.

What is Sinus polyp degeneration?

Sinus polyp degeneration (degeneration of abnormal tissue growths that grow inside the nasal passages and sinuses) is found to be associated with 44 drugs and 6 conditions by eHealthMe. Check the latest studies of Sinus polyp degeneration.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

24,254 people reported to have side effects when taking Phenergan.
Among them, 12 people (0.05%) have Sinus polyp degeneration.

Could Phenergan cause Sinus polyp degeneration?

Among these 12 people:

What is the gender of people who have Sinus polyp degeneration when taking Phenergan? *

female: 91.67 %
male: 8.33 %

What is the age of people who have Sinus polyp degeneration when taking Phenergan? *

What are other drugs people take besides Phenergan? *

What are other side effects people have besides Sinus polyp degeneration? *

Metastases To Bone (cancer spreads to bone): 12 people, 100.00%
Gingival Ulceration (ulcer on gums): 12 people, 100.00%
Hepatic Cyst: 12 people, 100.00%
High Blood Cholesterol: 12 people, 100.00%
Impaired Healing: 12 people, 100.00%
Inflammation: 12 people, 100.00%
Intervertebral Disc Degeneration (spinal disc degeneration): 12 people, 100.00%
Joint Pain: 12 people, 100.00%
Left Ventricular Hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart): 12 people, 100.00%
Lung Infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung): 12 people, 100.00%

What are the existing conditions these people have? *

Diabetes: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Phenergan and have Sinus polyp degeneration?

- Check whether Sinus polyp degeneration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Phenergan:

Phenergan (25,312 reports)

Browse all side effects of Phenergan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus polyp degeneration:

Sinus polyp degeneration (44 drugs)

Browse all the conditions that are associated with Sinus polyp degeneration:

Sinus polyp degeneration (6 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on promethazine hydrochloride (the active ingredients of Phenergan) and Phenergan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.