Phenytoin sodium and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Phenytoin sodium (phenytoin sodium), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Aspirin, and have Convulsion.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Phenytoin sodium. It is created by eHealthMe based on reports of 6,740 people who have side effects when taking Phenytoin sodium from the FDA, and is updated regularly.

What is Phenytoin sodium?

Phenytoin sodium has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 6,886 Phenytoin sodium users. Check the latest studies of Phenytoin sodium.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,088 drugs and 1,360 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

On Jul, 17, 2026

6,740 people reported to have side effects when taking Phenytoin sodium.
Among them, 11 people (0.16%) have Multiple sclerosis.

Could Phenytoin sodium cause Multiple sclerosis?

Among these 11 people:

How long have people been on Phenytoin sodium when they have Multiple sclerosis? *

What is the gender of people who have Multiple sclerosis when taking Phenytoin sodium? *

female: 36.36 %
male: 63.64 %

What is the age of people who have Multiple sclerosis when taking Phenytoin sodium? *

What are other drugs people take besides Phenytoin sodium? *

What are other side effects people have besides Multiple sclerosis? *

Central Nervous System Lesion (an abnormality in tissue of brain or spinal cord): 3 people, 27.27%
Memory Loss: 3 people, 27.27%
Drug Ineffective: 2 people, 18.18%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 18.18%
Weakness: 2 people, 18.18%
Depression: 2 people, 18.18%
Gait Disturbance: 2 people, 18.18%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 2 people, 18.18%
Hemiparesis (weakness on one side of the body): 2 people, 18.18%
Hair Loss: 1 person, 9.09%

What are the existing conditions these people have? *

Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 9.09%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 9.09%
Encephalitis (inflammation of the brain): 1 person, 9.09%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Phenytoin sodium and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Phenytoin sodium:

Phenytoin sodium (6,886 reports)

Browse all side effects of Phenytoin sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Multiple sclerosis (1,088 drugs)

Browse all the conditions that are associated with Multiple sclerosis:

Multiple sclerosis (1,360 conditions)

Related publications that referenced our studies

Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Akasaka E, Kayo SJ, Nakano H, Ishii N, Hashimoto T, Sawamura D, "Diaminodiphenyl Sulfone-Induced Hemolytic Anemia and Alopecia in a Case of Linear IgA Bullous Dermatosis", Case reports in dermatology, 2014 Jan .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Akasaka E, Kayo SJ, Nakano H, Ishii N, Hashimoto T, Sawamura D, "Diaminodiphenyl Sulfone-Induced Hemolytic Anemia and Alopecia in a Case of Linear IgA Bullous Dermatosis", Case reports in dermatology, 2014 Jan .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on phenytoin sodium (the active ingredients of Phenytoin sodium) and Phenytoin sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.