Phenytoin and Leukopenia - a phase IV clinical study of FDA data

Summary:

Leukopenia is reported as a side effect among people who take Phenytoin (phenytoin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Keppra, and have Convulsion.

The phase IV clinical study analyzes which people have Leukopenia when taking Phenytoin. It is created by eHealthMe based on reports of 15,464 people who have side effects when taking Phenytoin from the FDA, and is updated regularly.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

What is Leukopenia?

Leukopenia (less number of white blood cells in blood) is found to be associated with 1,682 drugs and 2,289 conditions by eHealthMe. Check the latest studies of Leukopenia.

On Jul, 15, 2026

15,464 people reported to have side effects when taking Phenytoin.
Among them, 88 people (0.57%) have Leukopenia.

Among these 88 people:

How long have people been on Phenytoin when they have Leukopenia? *

What is the gender of people who have Leukopenia when taking Phenytoin? *

female: 49.41 %
male: 50.59 %

What is the age of people who have Leukopenia when taking Phenytoin? *

What are other drugs people take besides Phenytoin? *

What are other side effects people have besides Leukopenia? *

Thrombocytopenia (decrease of platelets in blood): 28 people, 31.82%
Fever: 20 people, 22.73%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 17 people, 19.32%
Rashes (redness): 12 people, 13.64%
Gamma-Glutamyltransferase Increased: 10 people, 11.36%
Conjunctivitis (pink eye): 9 people, 10.23%
Vith Nerve Paralysis: 8 people, 9.09%
Sepsis (a severe blood infection that can lead to organ failure and death): 8 people, 9.09%
Meningitis Aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed): 8 people, 9.09%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 7 people, 7.95%

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 12 people, 13.64%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 5 people, 5.68%
Lower Respiratory Tract Infection: 4 people, 4.55%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 3.41%
Gastric Ulcer Haemorrhage (bleeding ulcer of stomach): 2 people, 2.27%
Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 2.27%
Partial Seizures (seizures which affect only a part of the brain at onset): 2 people, 2.27%
Multiple Myeloma (cancer of the plasma cells): 2 people, 2.27%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 2.27%
High Blood Pressure: 2 people, 2.27%

* Approximation only. Some reports may have incomplete information.

Do you take Phenytoin and have Leukopenia?

- Check whether Leukopenia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Phenytoin:

Phenytoin (15,753 reports)

Leukopenia treatments and more:

Leukopenia (58,665 reports)

Browse all side effects of Phenytoin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Leukopenia:

Leukopenia (1,682 drugs)

Browse all the conditions that are associated with Leukopenia:

Leukopenia (2,289 conditions)

Related publications that referenced our studies

Wandalkar P, Daswani BR, Pandit PT, Ghongane BB, "A case of Phenytoin toxicity", INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY, 2014 Jan .
Wandalkar P, Daswani BR, Pandit PT, Ghongane BB, "A case of Phenytoin toxicity", INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on phenytoin (the active ingredients of Phenytoin) and Phenytoin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.