Phosphatidyl serine and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Phosphatidyl serine (phosphatidylserine), especially for people who are female, 50-59 old, also take Msm, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Headache when taking Phosphatidyl serine. It is created by eHealthMe based on reports of 170 people who have side effects when taking Phosphatidyl serine from the FDA, and is updated regularly.

What is Phosphatidyl serine?

Phosphatidyl serine has active ingredients of phosphatidylserine. eHealthMe is studying from 206 Phosphatidyl serine users. Check the latest studies of Phosphatidyl serine.

What is Headache?

Headache (pain in head) is found to be associated with 3,754 drugs and 5,775 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 13, 2026

170 people reported to have side effects when taking Phosphatidyl serine.
Among them, 11 people (6.47%) have Headache.

Could Phosphatidyl serine cause Headache?

Among these 11 people:

What is the gender of people who have Headache when taking Phosphatidyl serine? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Headache when taking Phosphatidyl serine? *

What are other drugs people take besides Phosphatidyl serine? *

What are other side effects people have besides Headache? *

Blood Glucose Increased: 4 people, 36.36%
Fatigue (feeling of tiredness): 4 people, 36.36%
Nausea (feeling of having an urge to vomit): 4 people, 36.36%
Memory Loss: 3 people, 27.27%
Platelet Count Increased: 3 people, 27.27%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 27.27%
Flatulence (flatus expelled through the anus): 3 people, 27.27%
General Physical Condition Abnormal: 3 people, 27.27%
Haemoglobin Decreased: 3 people, 27.27%
Negative Thoughts: 3 people, 27.27%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 36.36%
Urination - Excessive Volume: 1 person, 9.09%
Immune System Disorder: 1 person, 9.09%
Bone Decalcification: 1 person, 9.09%
Bone Disorder: 1 person, 9.09%
Calcium Metabolism Disorder (occur when the body has too little or too much calcium): 1 person, 9.09%
Cardiac Disorder: 1 person, 9.09%
Heart Disease: 1 person, 9.09%
Hepatic Steatosis (fatty liver disease): 1 person, 9.09%
Hepatitis C Virus Test Positive: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Phosphatidyl serine and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Phosphatidyl serine:

Phosphatidyl serine (206 reports)

Headache treatments and more:

Headache (756,642 reports)

Browse all side effects of Phosphatidyl serine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,754 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,775 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on phosphatidylserine (the active ingredients of Phosphatidyl serine) and Phosphatidyl serine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.