Picato and Application site irritation - a phase IV clinical study of FDA data

Summary:

Application site irritation is reported as a side effect among people who take Picato (ingenol mebutate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Premarin, and have Actinic keratosis.

The phase IV clinical study analyzes which people have Application site irritation when taking Picato. It is created by eHealthMe based on reports of 5,498 people who have side effects when taking Picato from the FDA, and is updated regularly.

What is Picato?

Picato has active ingredients of ingenol mebutate. eHealthMe is studying from 5,498 Picato users. Check the latest studies of Picato.

What is Application site irritation?

Application site irritation is found to be associated with 392 drugs and 698 conditions by eHealthMe. Check the latest studies of Application site irritation.

On Jul, 15, 2026

5,498 people reported to have side effects when taking Picato.
Among them, 121 people (2.2%) have Application site irritation.

Could Picato cause Application site irritation?

Among these 121 people:

How long have people been on Picato when they have Application site irritation? *

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What is the gender of people who have Application site irritation when taking Picato? *

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What is the age of people who have Application site irritation when taking Picato? *

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* Approximation only. Some reports may have incomplete information.

Do you take Picato and have Application site irritation?

- Check whether Application site irritation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Picato:

Picato (5,498 reports)

Application site irritation treatments and more:

Application site irritation (12,156 reports)

How severe was Application site irritation and when was it recovered:

Application site irritation in Picato

Expand to all the drugs that have ingredients of ingenol mebutate:

Application site irritation and drugs with ingredients of ingenol mebutate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Picato:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site irritation:

Application site irritation (392 drugs)

Browse all the conditions that are associated with Application site irritation:

Application site irritation (698 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ingenol mebutate (the active ingredients of Picato) and Picato (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.