Picato and Eye pain - a phase IV clinical study of FDA data

Summary:

Eye pain is reported as a side effect among people who take Picato (ingenol mebutate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Baby Aspirin, and have Actinic keratosis.

The phase IV clinical study analyzes which people have Eye pain when taking Picato. It is created by eHealthMe based on reports of 5,498 people who have side effects when taking Picato from the FDA, and is updated regularly.

What is Picato?

Picato has active ingredients of ingenol mebutate. eHealthMe is studying from 5,498 Picato users. Check the latest studies of Picato.

What is Eye pain?

Eye pain is found to be associated with 1,749 drugs and 2,473 conditions by eHealthMe. Check the latest studies of Eye pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 27, 2026

5,498 people reported to have side effects when taking Picato.
Among them, 74 people (1.35%) have Eye pain.

Among these 74 people:

How long have people been on Picato when they have Eye pain? *

What is the gender of people who have Eye pain when taking Picato? *

female: 51.35 %
male: 48.65 %

What is the age of people who have Eye pain when taking Picato? *

What are other drugs people take besides Picato? *

What are other side effects people have besides Eye pain? *

Application Site Erythema (redness of the skin at application site): 23 people, 31.08%
Application Site Pain: 22 people, 29.73%
Eye Swelling: 19 people, 25.68%
Application Site Exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface): 15 people, 20.27%
Application Site Scab (hard coating on the skin formed at application site): 14 people, 18.92%
Eye Irritation: 14 people, 18.92%
Application Site Vesicles (small bubble within a cell at application site): 14 people, 18.92%
Headache (pain in head): 13 people, 17.57%
Application Site Swelling: 11 people, 14.86%
Ocular Hyperaemia (an abnormally large amount of blood in eye): 11 people, 14.86%

What are the existing conditions these people have? *

Actinic Keratosis (skin disease due to sun exposure): 56 people, 75.68%
Precancerous Skin Lesion: 5 people, 6.76%
High Blood Pressure: 3 people, 4.05%
High Blood Cholesterol: 3 people, 4.05%
Urinary Tract Disorder: 1 person, 1.35%
Thyroid Diseases: 1 person, 1.35%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 1.35%
Precancerous Cells Present: 1 person, 1.35%
Neck Pain: 1 person, 1.35%
Infection: 1 person, 1.35%

* Approximation only. Some reports may have incomplete information.

Do you take Picato and have Eye pain?

- Check whether Eye pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Picato:

Picato (5,498 reports)

Eye pain treatments and more:

Eye pain (57,871 reports)

Browse all side effects of Picato:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Eye pain:

Eye pain (1,749 drugs)

Browse all the conditions that are associated with Eye pain:

Eye pain (2,473 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ingenol mebutate (the active ingredients of Picato) and Picato (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.