Pioglitazone and Joint swelling - a phase IV clinical study of FDA data

Summary:

Joint swelling is reported as a side effect among people who take Pioglitazone (pioglitazone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Metformin, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Joint swelling when taking Pioglitazone. It is created by eHealthMe based on reports of 12,725 people who have side effects when taking Pioglitazone from the FDA, and is updated regularly.

What is Pioglitazone?

Pioglitazone has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 12,864 Pioglitazone users. Check the latest studies of Pioglitazone.

What is Joint swelling?

Joint swelling is found to be associated with 2,122 drugs and 2,936 conditions by eHealthMe. Check the latest studies of Joint swelling.

On Jul, 29, 2026

12,725 people reported to have side effects when taking Pioglitazone.
Among them, 77 people (0.61%) have Joint swelling.

Could Pioglitazone cause Joint swelling?

Among these 77 people:

How long have people been on Pioglitazone when they have Joint swelling? *

What is the gender of people who have Joint swelling when taking Pioglitazone? *

female: 53.42 %
male: 46.58 %

What is the age of people who have Joint swelling when taking Pioglitazone? *

What are other drugs people take besides Pioglitazone? *

What are other side effects people have besides Joint swelling? *

Peripheral Swelling: 26 people, 33.77%
Weakness: 24 people, 31.17%
Pain: 20 people, 25.97%
Joint Pain: 19 people, 24.68%
Weight Increased: 15 people, 19.48%
Dyspnea (difficult or laboured breathing): 14 people, 18.18%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 13 people, 16.88%
High Blood Pressure: 13 people, 16.88%
Hypoaesthesia (reduced sense of touch or sensation): 13 people, 16.88%
Back Pain: 12 people, 15.58%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 10 people, 12.99%
High Blood Pressure: 9 people, 11.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 9.09%
Pain: 7 people, 9.09%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 7.79%
Urticaria (rash of round, red welts on the skin that itch intensely): 5 people, 6.49%
High Blood Cholesterol: 5 people, 6.49%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 5.19%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.19%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

Do you take Pioglitazone and have Joint swelling?

- Check whether Joint swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pioglitazone:

Pioglitazone (12,864 reports)

Joint swelling treatments and more:

Joint swelling (143,797 reports)

Browse all side effects of Pioglitazone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint swelling:

Joint swelling (2,122 drugs)

Browse all the conditions that are associated with Joint swelling:

Joint swelling (2,936 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Pioglitazone) and Pioglitazone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.