Pioglitazone and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Pioglitazone (pioglitazone hydrochloride), especially for people who are male, 50-59 old, also take Actos, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Sciatica when taking Pioglitazone. It is created by eHealthMe based on reports of 12,725 people who have side effects when taking Pioglitazone from the FDA, and is updated regularly.

What is Pioglitazone?

Pioglitazone has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 12,864 Pioglitazone users. Check the latest studies of Pioglitazone.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,137 drugs and 1,433 conditions by eHealthMe. Check the latest studies of Sciatica.

On Jul, 14, 2026

12,725 people reported to have side effects when taking Pioglitazone.
Among them, 28 people (0.22%) have Sciatica.

Among these 28 people:

What is the gender of people who have Sciatica when taking Pioglitazone? *

female: 34.62 %
male: 65.38 %

What is the age of people who have Sciatica when taking Pioglitazone? *

What are other drugs people take besides Pioglitazone? *

What are other side effects people have besides Sciatica? *

Joint Pain: 16 people, 57.14%
Pain: 15 people, 53.57%
Depression: 15 people, 53.57%
Discomfort: 15 people, 53.57%
Fibromyalgia (a long-term condition which causes pain all over the body): 14 people, 50.00%
Stress And Anxiety: 14 people, 50.00%
Myelitis Transverse (a neurological condition consisting of an inflammatory process of the spinal cord): 14 people, 50.00%
Pleural Fibrosis (formation of fibrous tissue in lung): 14 people, 50.00%
Haematochezia (passage of stools containing blood): 14 people, 50.00%
Emotional Distress: 14 people, 50.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 16 people, 57.14%
High Blood Pressure: 7 people, 25.00%
Depression: 3 people, 10.71%
Platelet Aggregation Inhibition: 3 people, 10.71%
Pain: 3 people, 10.71%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 10.71%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 10.71%
High Blood Cholesterol: 2 people, 7.14%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 7.14%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Pioglitazone and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pioglitazone:

Pioglitazone (12,864 reports)

Sciatica treatments and more:

Sciatica (28,509 reports)

Browse all side effects of Pioglitazone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,137 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,433 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pioglitazone hydrochloride (the active ingredients of Pioglitazone) and Pioglitazone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.