Plaquenil and Osteosclerosis - a phase IV clinical study of FDA data

Summary:

Osteosclerosis is reported as a side effect among people who take Plaquenil (hydroxychloroquine sulfate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Nasonex, and have Arthritis.

The phase IV clinical study analyzes which people have Osteosclerosis when taking Plaquenil. It is created by eHealthMe based on reports of 88,348 people who have side effects when taking Plaquenil from the FDA, and is updated regularly.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 91,016 Plaquenil users. Check the latest studies of Plaquenil.

What is Osteosclerosis?

Osteosclerosis (an elevation in bone density) is found to be associated with 645 drugs and 399 conditions by eHealthMe. Check the latest studies of Osteosclerosis.

On Apr, 13, 2026

88,348 people reported to have side effects when taking Plaquenil.
Among them, 125 people (0.14%) have Osteosclerosis.

Among these 125 people:

* Approximation only. Some reports may have incomplete information.

Do you take Plaquenil and have Osteosclerosis?

- Check whether Osteosclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Plaquenil:

Plaquenil (91,016 reports)

Osteosclerosis treatments and more:

Osteosclerosis (2,741 reports)

How severe was Osteosclerosis and when was it recovered:

Osteosclerosis in Plaquenil

Expand to all the drugs that have ingredients of hydroxychloroquine sulfate:

Osteosclerosis and drugs with ingredients of hydroxychloroquine sulfate (164 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Plaquenil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteosclerosis:

Osteosclerosis (645 drugs)

Browse all the conditions that are associated with Osteosclerosis:

Osteosclerosis (399 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydroxychloroquine sulfate (the active ingredients of Plaquenil) and Plaquenil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.