Plavix and Aortic valve replacement - a phase IV clinical study of FDA data

Summary:

Aortic valve replacement is reported as a side effect among people who take Plavix (clopidogrel bisulfate), especially for people who are male, 60+ old, have been taking the drug for 10+ years also take Aspirin, and have Arthritis.

The phase IV clinical study analyzes which people have Aortic valve replacement when taking Plavix. It is created by eHealthMe based on reports of 147,094 people who have side effects when taking Plavix from the FDA, and is updated regularly.

What is Plavix?

Plavix has active ingredients of clopidogrel bisulfate. It is often used in stent. eHealthMe is studying from 151,179 Plavix users. Check the latest studies of Plavix.

What is Aortic valve replacement?

Aortic valve replacement is found to be associated with 193 drugs and 329 conditions by eHealthMe. Check the latest studies of Aortic valve replacement.

On Aug, 11, 2026

147,094 people reported to have side effects when taking Plavix.
Among them, 48 people (0.03%) have Aortic valve replacement.

Could Plavix cause Aortic valve replacement?

Among these 48 people:

How long have people been on Plavix when they have Aortic valve replacement? *

What is the gender of people who have Aortic valve replacement when taking Plavix? *

female: 48.89 %
male: 51.11 %

What is the age of people who have Aortic valve replacement when taking Plavix? *

What are other drugs people take besides Plavix? *

Aspirin: 11 people, 22.92%
Lipitor: 9 people, 18.75%
Coumadin: 6 people, 12.50%
Synthroid: 5 people, 10.42%
Zetia: 5 people, 10.42%
Xyrem: 5 people, 10.42%
Lantus: 5 people, 10.42%
Vitamin B12: 5 people, 10.42%
Avandia: 4 people, 8.33%
Citalopram Hydrobromide: 4 people, 8.33%

What are other side effects people have besides Aortic valve replacement? *

Aortic Stenosis (obstruction to the outflow of blood from the left ventricle into the aorta): 8 people, 16.67%
Dyspnea (difficult or laboured breathing): 7 people, 14.58%
Dehydration (dryness resulting from the removal of water): 6 people, 12.50%
Fatigue (feeling of tiredness): 6 people, 12.50%
Pneumonia: 6 people, 12.50%
Dizziness: 6 people, 12.50%
Headache (pain in head): 6 people, 12.50%
Nausea (feeling of having an urge to vomit): 5 people, 10.42%
Cardiac Murmur (an heart sound in valve abnormality): 5 people, 10.42%
High Blood Pressure: 5 people, 10.42%

What are the existing conditions these people have? *

Diabetes: 6 people, 12.50%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 12.50%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 10.42%
High Blood Cholesterol: 5 people, 10.42%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 10.42%
Sleep Disorder: 3 people, 6.25%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.25%
Dyspnea (difficult or laboured breathing): 3 people, 6.25%
Hypersensitivity: 3 people, 6.25%
Cardiac Disorder: 2 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Plavix and have Aortic valve replacement?

- Check whether Aortic valve replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Plavix:

Plavix (151,179 reports)

Browse all side effects of Plavix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic valve replacement:

Aortic valve replacement (193 drugs)

Browse all the conditions that are associated with Aortic valve replacement:

Aortic valve replacement (329 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on clopidogrel bisulfate (the active ingredients of Plavix) and Plavix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.