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Pramine and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Pramine (imipramine hydrochloride), especially for people who are male, 40-49 old, also take Avonex, and have Insomnia.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Pramine. It is created by eHealthMe based on reports of 7,187 people who have side effects when taking Pramine from the FDA, and is updated regularly.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,088 drugs and 1,360 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

On Jul, 11, 2026

7,187 people reported to have side effects when taking Pramine.
Among them, 28 people (0.39%) have Multiple sclerosis.

Could Pramine cause Multiple sclerosis?

Among these 28 people:

What is the gender of people who have Multiple sclerosis when taking Pramine? *

  • female: 50 %
  • male: 50 %

What is the age of people who have Multiple sclerosis when taking Pramine? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 8.33 %
  • 40-49: 45.83 %
  • 50-59: 29.17 %
  • 60+: 16.67 %

What are other drugs people take besides Pramine? *

  1. Avonex: 10 people, 35.71%
  2. Baclofen: 9 people, 32.14%
  3. Tysabri: 7 people, 25.00%
  4. Ambien: 7 people, 25.00%
  5. Morphine: 5 people, 17.86%
  6. Motrin: 5 people, 17.86%
  7. Vancomycin: 5 people, 17.86%
  8. Wellbutrin: 5 people, 17.86%
  9. Oxycontin: 4 people, 14.29%
  10. Protonix: 4 people, 14.29%

What are other side effects people have besides Multiple sclerosis? *

  1. Balance Disorder: 7 people, 25.00%
  2. Weight Decreased: 6 people, 21.43%
  3. Hypoaesthesia (reduced sense of touch or sensation): 6 people, 21.43%
  4. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 5 people, 17.86%
  5. Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 5 people, 17.86%
  6. Weakness: 5 people, 17.86%
  7. Haematochezia (passage of stools containing blood): 5 people, 17.86%
  8. Dysgraphia (impaired ability to learn to write): 5 people, 17.86%
  9. Speech Impairment (Adult) (inability to speak (adult)): 5 people, 17.86%
  10. Blood Iron Decreased: 5 people, 17.86%

What are the existing conditions these people have? *

  1. Insomnia (sleeplessness): 2 people, 7.14%
  2. Urination - Excessive Volume: 1 person, 3.57%
  3. Sleep Disorder: 1 person, 3.57%
  4. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 3.57%
  5. Panic Disorder: 1 person, 3.57%
  6. Pain: 1 person, 3.57%
  7. Itching: 1 person, 3.57%
  8. Ill-Defined Disorder: 1 person, 3.57%
  9. Depression: 1 person, 3.57%
  10. Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Pramine and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pramine:

Multiple sclerosis treatments and more:

How severe was Multiple sclerosis and when was it recovered:

Expand to all the drugs that have ingredients of imipramine hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Pramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Browse all the conditions that are associated with Multiple sclerosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on imipramine hydrochloride (the active ingredients of Pramine) and Pramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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