Pramine and Orthostatic hypotension - a phase IV clinical study of FDA data

Summary:

Orthostatic hypotension is reported as a side effect among people who take Pramine (imipramine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Flonase, and have Pain.

The phase IV clinical study analyzes which people have Orthostatic hypotension when taking Pramine. It is created by eHealthMe based on reports of 7,187 people who have side effects when taking Pramine from the FDA, and is updated regularly.

What is Pramine?

Pramine has active ingredients of imipramine hydrochloride. eHealthMe is studying from 7,461 Pramine users. Check the latest studies of Pramine.

What is Orthostatic hypotension?

Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up) is found to be associated with 1,233 drugs and 1,336 conditions by eHealthMe. Check the latest studies of Orthostatic hypotension.

On Aug, 09, 2026

7,187 people reported to have side effects when taking Pramine.
Among them, 48 people (0.67%) have Orthostatic hypotension.

Could Pramine cause Orthostatic hypotension?

Among these 48 people:

How long have people been on Pramine when they have Orthostatic hypotension? *

What is the gender of people who have Orthostatic hypotension when taking Pramine? *

female: 45.65 %
male: 54.35 %

What is the age of people who have Orthostatic hypotension when taking Pramine? *

What are other drugs people take besides Pramine? *

What are other side effects people have besides Orthostatic hypotension? *

Fatigue (feeling of tiredness): 24 people, 50.00%
Back Pain: 21 people, 43.75%
Diarrhea: 20 people, 41.67%
Pain: 20 people, 41.67%
Headache (pain in head): 20 people, 41.67%
Stress And Anxiety: 20 people, 41.67%
Hypoaesthesia (reduced sense of touch or sensation): 20 people, 41.67%
Depression: 20 people, 41.67%
Joint Pain: 18 people, 37.50%
High Blood Cholesterol: 17 people, 35.42%

What are the existing conditions these people have? *

Pain: 16 people, 33.33%
Prostate Cancer: 14 people, 29.17%
Bone Density Abnormal: 14 people, 29.17%
Depression: 5 people, 10.42%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 4 people, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 8.33%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 4 people, 8.33%
Migraine (headache): 3 people, 6.25%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 4.17%
Bipolar Disorder (mood disorder): 2 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Pramine and have Orthostatic hypotension?

- Check whether Orthostatic hypotension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pramine:

Pramine (7,461 reports)

Browse all side effects of Pramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,233 drugs)

Browse all the conditions that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,336 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on imipramine hydrochloride (the active ingredients of Pramine) and Pramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.