Pregabalin and Angular cheilitis - a phase IV clinical study of FDA data

Summary:

Angular cheilitis is reported as a side effect among people who take Pregabalin (pregabalin), especially for people who are female, 60+ old, also take Methotrexate, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Angular cheilitis when taking Pregabalin. It is created by eHealthMe based on reports of 73,056 people who have side effects when taking Pregabalin from the FDA, and is updated regularly.

What is Pregabalin?

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,069 Pregabalin users. Check the latest studies of Pregabalin.

What is Angular cheilitis?

Angular cheilitis (inflammation of one, or more commonly both, of the corners of the mouth) is found to be associated with 72 drugs and 244 conditions by eHealthMe. Check the latest studies of Angular cheilitis.

On Jul, 29, 2026

73,056 people reported to have side effects when taking Pregabalin.
Among them, 18 people (0.02%) have Angular cheilitis.

Could Pregabalin cause Angular cheilitis?

Among these 18 people:

What is the gender of people who have Angular cheilitis when taking Pregabalin? *

female: 100 %
male: 0.0 %

What is the age of people who have Angular cheilitis when taking Pregabalin? *

What are other drugs people take besides Pregabalin? *

What are other side effects people have besides Angular cheilitis? *

Fatigue (feeling of tiredness): 14 people, 77.78%
Nasopharyngitis (inflammation of the nasopharynx): 12 people, 66.67%
Blood Pressure Systolic Increased: 8 people, 44.44%
Oxygen Saturation Decreased: 8 people, 44.44%
Wound Infection: 6 people, 33.33%
Hoarseness Or Changing Voice: 6 people, 33.33%
Nail Injury: 6 people, 33.33%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 6 people, 33.33%
Limb Injury: 6 people, 33.33%
Joint Swelling: 6 people, 33.33%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 44.44%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 7 people, 38.89%
Joint Pain: 6 people, 33.33%
Birth Control: 4 people, 22.22%
Vaginal Bleeding Between Periods: 2 people, 11.11%
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 2 people, 11.11%
Iron Deficiency Anaemia: 2 people, 11.11%
Insomnia (sleeplessness): 2 people, 11.11%
Depression: 2 people, 11.11%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Pregabalin and have Angular cheilitis?

- Check whether Angular cheilitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pregabalin:

Pregabalin (74,069 reports)

Browse all side effects of Pregabalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Angular cheilitis:

Angular cheilitis (72 drugs)

Browse all the conditions that are associated with Angular cheilitis:

Angular cheilitis (244 conditions)

Related publications that referenced our studies

de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Bonnet U, Taazimi B, Grabbe HD, "Pregabalin-Related Hypertriglyceridemia", Psychosomatics, 2014 Nov .
de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Bonnet U, Taazimi B, Grabbe HD, "Pregabalin-Related Hypertriglyceridemia", Psychosomatics, 2014 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on pregabalin (the active ingredients of Pregabalin) and Pregabalin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.