Pregabalin and Left ventricular dysfunction - a phase IV clinical study of FDA data

Summary:

Left ventricular dysfunction is reported as a side effect among people who take Pregabalin (pregabalin), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Metformin, and have High blood pressure.

The phase IV clinical study analyzes which people have Left ventricular dysfunction when taking Pregabalin. It is created by eHealthMe based on reports of 73,056 people who have side effects when taking Pregabalin from the FDA, and is updated regularly.

What is Pregabalin?

Pregabalin has active ingredients of pregabalin. It is often used in fibromyalgia. eHealthMe is studying from 74,069 Pregabalin users. Check the latest studies of Pregabalin.

What is Left ventricular dysfunction?

Left ventricular dysfunction is found to be associated with 892 drugs and 792 conditions by eHealthMe. Check the latest studies of Left ventricular dysfunction.

On Jul, 10, 2026

73,056 people reported to have side effects when taking Pregabalin.
Among them, 39 people (0.05%) have Left ventricular dysfunction.

Could Pregabalin cause Left ventricular dysfunction?

Among these 39 people:

How long have people been on Pregabalin when they have Left ventricular dysfunction? *

What is the gender of people who have Left ventricular dysfunction when taking Pregabalin? *

female: 47.22 %
male: 52.78 %

What is the age of people who have Left ventricular dysfunction when taking Pregabalin? *

What are other drugs people take besides Pregabalin? *

Aspirin: 5 people, 12.82%
Metformin: 5 people, 12.82%
Levothyroxine Sodium: 4 people, 10.26%
Metaxalone: 4 people, 10.26%
Fluoxetine: 4 people, 10.26%
Doxycycline: 4 people, 10.26%
Clopidogrel: 4 people, 10.26%
Nadolol: 4 people, 10.26%
Aripiprazole: 3 people, 7.69%
Duloxetine Hydrochloride: 3 people, 7.69%

What are other side effects people have besides Left ventricular dysfunction? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 17.95%
Hypotension (abnormally low blood pressure): 6 people, 15.38%
Tricuspid Valve Incompetence (inefficient heart valve): 6 people, 15.38%
Nausea And Vomiting: 5 people, 12.82%
Chest Pain: 5 people, 12.82%
Mitral Valve Incompetence (inefficient heart valve): 5 people, 12.82%
High Blood Pressure: 5 people, 12.82%
Chronic Kidney Disease: 4 people, 10.26%
Pharyngitis (inflammation of the pharynx, causing a sore throat): 4 people, 10.26%
Acute Myocardial Infarction (acute heart attack): 4 people, 10.26%

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 17.95%
Arrhythmias (irregular heartbeat): 5 people, 12.82%
Depression: 4 people, 10.26%
Fainting (loss of consciousness and postural tone): 4 people, 10.26%
Cardiac Failure: 3 people, 7.69%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 7.69%
Depressed Mood: 3 people, 7.69%
Weight Increased: 2 people, 5.13%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 5.13%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Pregabalin and have Left ventricular dysfunction?

- Check whether Left ventricular dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pregabalin:

Pregabalin (74,069 reports)

Browse all side effects of Pregabalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (892 drugs)

Browse all the conditions that are associated with Left ventricular dysfunction:

Left ventricular dysfunction (792 conditions)

Related publications that referenced our studies

de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Bonnet U, Taazimi B, Grabbe HD, "Pregabalin-Related Hypertriglyceridemia", Psychosomatics, 2014 Nov .
de Landaluce, L. O., Carbonell, P., Asensio, C., Escoda, N., López, P., & Laporte, J. R. , "Gabapentin and Pregabalin and Risk of Atrial Fibrillation in the Elderly: A Population-Based Cohort Study in an Electronic Prescription Database", Drug safety, 2018 Jan .
Bonnet U, Taazimi B, Grabbe HD, "Pregabalin-Related Hypertriglyceridemia", Psychosomatics, 2014 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on pregabalin (the active ingredients of Pregabalin) and Pregabalin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.