Premarin and Appendicitis perforated - a phase IV clinical study of FDA data

Summary:

Appendicitis perforated is reported as a side effect among people who take Premarin (estrogens, conjugated), especially for people who are female, 50-59 old, also take Synthroid, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Appendicitis perforated when taking Premarin. It is created by eHealthMe based on reports of 98,531 people who have side effects when taking Premarin from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Appendicitis perforated?

Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts) is found to be associated with 368 drugs and 554 conditions by eHealthMe. Check the latest studies of Appendicitis perforated.

On Jul, 15, 2026

98,531 people reported to have side effects when taking Premarin.
Among them, 14 people (0.01%) have Appendicitis perforated.

Could Premarin cause Appendicitis perforated?

Among these 14 people:

What is the gender of people who have Appendicitis perforated when taking Premarin? *

female: 100 %
male: 0.0 %

What is the age of people who have Appendicitis perforated when taking Premarin? *

What are other drugs people take besides Premarin? *

What are other side effects people have besides Appendicitis perforated? *

Abdominal Pain: 4 people, 28.57%
Weakness: 4 people, 28.57%
Fatigue (feeling of tiredness): 4 people, 28.57%
Drug Effect Decreased: 4 people, 28.57%
Nausea (feeling of having an urge to vomit): 4 people, 28.57%
Nausea And Vomiting: 4 people, 28.57%
Hot Flush (sudden feelings of heat): 4 people, 28.57%
Diarrhea: 3 people, 21.43%
Fall: 3 people, 21.43%
Dizziness: 3 people, 21.43%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 3 people, 21.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 21.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 7.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 7.14%
Multiple Allergies (allergy to multiple agents): 1 person, 7.14%
High Blood Cholesterol: 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%
Gait Disturbance: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and have Appendicitis perforated?

- Check whether Appendicitis perforated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premarin:

Premarin (99,630 reports)

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Appendicitis perforated:

Appendicitis perforated (368 drugs)

Browse all the conditions that are associated with Appendicitis perforated:

Appendicitis perforated (554 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated (the active ingredients of Premarin) and Premarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.