Premarin and Bone lesion - a phase IV clinical study of FDA data

Summary:

Bone lesion is reported as a side effect among people who take Premarin (estrogens, conjugated), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Zometa, and have Osteopenia.

The phase IV clinical study analyzes which people have Bone lesion when taking Premarin. It is created by eHealthMe based on reports of 98,531 people who have side effects when taking Premarin from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Bone lesion?

Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries) is found to be associated with 854 drugs and 501 conditions by eHealthMe. Check the latest studies of Bone lesion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

98,531 people reported to have side effects when taking Premarin.
Among them, 48 people (0.05%) have Bone lesion.

Among these 48 people:

How long have people been on Premarin when they have Bone lesion? *

What is the gender of people who have Bone lesion when taking Premarin? *

female: 93.62 %
male: 6.38 %

What is the age of people who have Bone lesion when taking Premarin? *

What are other drugs people take besides Premarin? *

What are other side effects people have besides Bone lesion? *

Spinal Osteoarthritis (joint cartilage loss in spine): 43 people, 89.58%
Joint Pain: 34 people, 70.83%
Osteoporosis (bones weak and more likely to break): 34 people, 70.83%
Osteonecrosis Of Jaw (death of bone of jaw): 33 people, 68.75%
Stress And Anxiety: 32 people, 66.67%
Pain: 31 people, 64.58%
Back Pain: 31 people, 64.58%
Diarrhea: 29 people, 60.42%
Pain In Extremity: 28 people, 58.33%
Fever: 28 people, 58.33%

What are the existing conditions these people have? *

Osteopenia (a condition where bone mineral density is lower than normal): 12 people, 25.00%
Multiple Myeloma (cancer of the plasma cells): 9 people, 18.75%
Breast Cancer: 5 people, 10.42%
Lung Neoplasm Malignant (cancer tumour of lung): 3 people, 6.25%
Depression: 3 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.25%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 2 people, 4.17%
Metastases To Bone (cancer spreads to bone): 2 people, 4.17%
Pain: 2 people, 4.17%
Eczema Nummular (circular or oval patches of eczema with well-defined edges): 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and have Bone lesion?

- Check whether Bone lesion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premarin:

Premarin (99,630 reports)

Bone lesion treatments and more:

Bone lesion (6,686 reports)

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone lesion:

Bone lesion (854 drugs)

Browse all the conditions that are associated with Bone lesion:

Bone lesion (501 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated (the active ingredients of Premarin) and Premarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.