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Premarin and Gallbladder attack - a phase IV clinical study of FDA data

Summary:

Gallbladder attack is reported as a side effect among people who take Premarin (estrogens, conjugated), especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years also take Synthroid, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Gallbladder attack when taking Premarin. It is created by eHealthMe based on reports of 98,531 people who have side effects when taking Premarin from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Gallbladder attack?

Gallbladder attack (gallstones, gallbladder disease and gallbladder pain) is found to be associated with 577 drugs and 995 conditions by eHealthMe. Check the latest studies of Gallbladder attack.

On Apr, 27, 2026

98,531 people reported to have side effects when taking Premarin.
Among them, 24 people (0.02%) have Gallbladder attack.

Could Premarin cause Gallbladder attack?

Among these 24 people:

How long have people been on Premarin when they have Gallbladder attack? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Gallbladder attack when taking Premarin? *

  • female: 95.83 %
  • male: 4.17 %

What is the age of people who have Gallbladder attack when taking Premarin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 5 %
  • 40-49: 10 %
  • 50-59: 50 %
  • 60+: 35 %

What are other drugs people take besides Premarin? *

  1. Synthroid: 10 people, 41.67%
  2. Toradol: 9 people, 37.50%
  3. Provera: 9 people, 37.50%
  4. Lipitor: 9 people, 37.50%
  5. Zofran: 9 people, 37.50%
  6. Zestril: 9 people, 37.50%
  7. Taxol: 8 people, 33.33%
  8. Compazine: 8 people, 33.33%
  9. Herceptin: 8 people, 33.33%
  10. Coumadin: 8 people, 33.33%

What are other side effects people have besides Gallbladder attack? *

  1. Dizziness: 10 people, 41.67%
  2. Loss Of Consciousness: 10 people, 41.67%
  3. Stress And Anxiety: 9 people, 37.50%
  4. Cardiomyopathy (weakening of the heart muscle): 8 people, 33.33%
  5. Impaired Healing: 8 people, 33.33%
  6. Pleural Effusion (water on the lungs): 8 people, 33.33%
  7. Hypocalcaemia (levels of calcium in blood serum are abnormally low): 8 people, 33.33%
  8. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 8 people, 33.33%
  9. Chest Pain: 8 people, 33.33%
  10. Pulmonary Mass: 8 people, 33.33%

What are the existing conditions these people have? *

  1. High Blood Pressure: 10 people, 41.67%
  2. High Blood Cholesterol: 10 people, 41.67%
  3. Breast Cancer Metastatic: 8 people, 33.33%
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 33.33%
  5. Stress And Anxiety: 3 people, 12.50%
  6. Pain: 2 people, 8.33%
  7. Arrhythmias (irregular heartbeat): 2 people, 8.33%
  8. Hot Flush (sudden feelings of heat): 2 people, 8.33%
  9. Gastritis (inflammation of stomach): 1 person, 4.17%
  10. Aggression: 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and have Gallbladder attack?

- Check whether Gallbladder attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premarin:

Gallbladder attack treatments and more:

How severe was Gallbladder attack and when was it recovered:

Expand to all the drugs that have ingredients of estrogens, conjugated:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder attack:

Browse all the conditions that are associated with Gallbladder attack:

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated (the active ingredients of Premarin) and Premarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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