Premarin and Hypercoagulation - a phase IV clinical study of FDA data

Summary:

Hypercoagulation is reported as a side effect among people who take Premarin (estrogens, conjugated), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Ativan, and have Assisted fertilisation.

The phase IV clinical study analyzes which people have Hypercoagulation when taking Premarin. It is created by eHealthMe based on reports of 98,531 people who have side effects when taking Premarin from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Hypercoagulation?

Hypercoagulation (increased tendency for clotting of the blood) is found to be associated with 421 drugs and 533 conditions by eHealthMe. Check the latest studies of Hypercoagulation.

On Jan, 13, 2026

98,531 people reported to have side effects when taking Premarin.
Among them, 14 people (0.01%) have Hypercoagulation.

Among these 14 people:

How long have people been on Premarin when they have Hypercoagulation? *

What is the gender of people who have Hypercoagulation when taking Premarin? *

female: 100 %
male: 0.0 %

What is the age of people who have Hypercoagulation when taking Premarin? *

What are other drugs people take besides Premarin? *

What are other side effects people have besides Hypercoagulation? *

Dehydration (dryness resulting from the removal of water): 4 people, 28.57%
International Normalised Ratio Increased: 4 people, 28.57%
Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 3 people, 21.43%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 21.43%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 3 people, 21.43%
Memory Loss: 3 people, 21.43%
Pain: 3 people, 21.43%
Pleural Effusion (water on the lungs): 3 people, 21.43%
Jugular Vein Thrombosis (clot in jugular vein): 3 people, 21.43%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 21.43%

What are the existing conditions these people have? *

Pain: 2 people, 14.29%
Assisted Fertilisation: 2 people, 14.29%
Left Ventricular Dysfunction: 1 person, 7.14%
Heart Rate Irregular: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and have Hypercoagulation?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premarin:

Premarin (99,630 reports)

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercoagulation:

Hypercoagulation (421 drugs)

Browse all the conditions that are associated with Hypercoagulation:

Hypercoagulation (533 conditions)

Drugs similar to Premarin and Hypercoagulation :

Estradiol side effect: Hypercoagulation

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated (the active ingredients of Premarin) and Premarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.