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Premarin and Leukocytoclastic vasculitis - a phase IV clinical study of FDA data

Summary:

Leukocytoclastic vasculitis is reported as a side effect among people who take Premarin (estrogens, conjugated), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Prednisone, and have High blood pressure.

The phase IV clinical study analyzes which people have Leukocytoclastic vasculitis when taking Premarin. It is created by eHealthMe based on reports of 98,531 people who have side effects when taking Premarin from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Leukocytoclastic vasculitis?

Leukocytoclastic vasculitis (inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura) is found to be associated with 306 drugs and 675 conditions by eHealthMe. Check the latest studies of Leukocytoclastic vasculitis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

98,531 people reported to have side effects when taking Premarin.
Among them, 26 people (0.03%) have Leukocytoclastic vasculitis.

Could Premarin cause Leukocytoclastic vasculitis?

Among these 26 people:

How long have people been on Premarin when they have Leukocytoclastic vasculitis? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 100 %

What is the gender of people who have Leukocytoclastic vasculitis when taking Premarin? *

  • female: 96.15 %
  • male: 3.85 %

What is the age of people who have Leukocytoclastic vasculitis when taking Premarin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 4.76 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 19.05 %
  • 50-59: 14.29 %
  • 60+: 61.9 %

What are other drugs people take besides Premarin? *

  1. Lasix: 5 people, 19.23%
  2. Celebrex: 5 people, 19.23%
  3. Prednisone: 5 people, 19.23%
  4. Dyazide: 4 people, 15.38%
  5. Remicade: 4 people, 15.38%
  6. Provera: 3 people, 11.54%
  7. Coumadin: 3 people, 11.54%
  8. Pegasys: 3 people, 11.54%
  9. Claritin: 3 people, 11.54%
  10. Copegus: 3 people, 11.54%

What are other side effects people have besides Leukocytoclastic vasculitis? *

  1. Anaemia (lack of blood): 6 people, 23.08%
  2. Headache (pain in head): 5 people, 19.23%
  3. Joint Pain: 4 people, 15.38%
  4. Nausea (feeling of having an urge to vomit): 4 people, 15.38%
  5. Diarrhea: 4 people, 15.38%
  6. Fever: 4 people, 15.38%
  7. Neck Pain: 4 people, 15.38%
  8. Vasculitis (inflammation of a blood vessel or blood vessels): 4 people, 15.38%
  9. Stress And Anxiety: 4 people, 15.38%
  10. Weight Decreased: 4 people, 15.38%

What are the existing conditions these people have? *

  1. High Blood Pressure: 4 people, 15.38%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 11.54%
  3. Osteoporosis (bones weak and more likely to break): 2 people, 7.69%
  4. Menopausal Symptoms: 2 people, 7.69%
  5. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 3.85%
  6. Neoplasm Malignant (cancer tumour): 1 person, 3.85%
  7. Metastases To Bone (cancer spreads to bone): 1 person, 3.85%
  8. Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 3.85%
  9. Hypercalcaemia (elevated calcium (ca+) level in the blood): 1 person, 3.85%
  10. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and have Leukocytoclastic vasculitis?

- Check whether Leukocytoclastic vasculitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premarin:

Leukocytoclastic vasculitis treatments and more:

How severe was Leukocytoclastic vasculitis and when was it recovered:

Expand to all the drugs that have ingredients of estrogens, conjugated:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Leukocytoclastic vasculitis:

Browse all the conditions that are associated with Leukocytoclastic vasculitis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated (the active ingredients of Premarin) and Premarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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