Premarin and Retinal disorder - a phase IV clinical study of FDA data

Summary:

Retinal disorder is reported as a side effect among people who take Premarin (estrogens, conjugated), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Provera, and have Osteoporosis.

The phase IV clinical study analyzes which people have Retinal disorder when taking Premarin. It is created by eHealthMe based on reports of 98,531 people who have side effects when taking Premarin from the FDA, and is updated regularly.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

What is Retinal disorder?

Retinal disorder (disease of retina) is found to be associated with 325 drugs and 502 conditions by eHealthMe. Check the latest studies of Retinal disorder.



On Jul, 11, 2026

98,531 people reported to have side effects when taking Premarin.
Among them, 33 people (0.03%) have Retinal disorder.

Could Premarin cause Retinal disorder?

Among these 33 people:

How long have people been on Premarin when they have Retinal disorder? *

  • < 1 month: 25 %
  • 1 - 6 months: 25 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Retinal disorder when taking Premarin? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Retinal disorder when taking Premarin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 13.33 %
  • 50-59: 33.33 %
  • 60+: 53.33 %

What are other drugs people take besides Premarin? *

  1. Provera: 13 people, 39.39%
  2. Prozac: 10 people, 30.30%
  3. Lipitor: 9 people, 27.27%
  4. Fosamax: 6 people, 18.18%
  5. Synthroid: 5 people, 15.15%
  6. Vitamins: 5 people, 15.15%
  7. Alendronate Sodium: 4 people, 12.12%
  8. Vitamin E: 4 people, 12.12%
  9. Keppra: 3 people, 9.09%
  10. Neurontin: 3 people, 9.09%

What are other side effects people have besides Retinal disorder? *

  1. Cataract (clouding of the lens inside the eye): 15 people, 45.45%
  2. Joint Pain: 12 people, 36.36%
  3. Balance Disorder: 11 people, 33.33%
  4. Visual Acuity Reduced (reduced clearness of vision): 11 people, 33.33%
  5. Fall: 10 people, 30.30%
  6. Dizziness: 10 people, 30.30%
  7. Headache (pain in head): 10 people, 30.30%
  8. High Blood Pressure: 9 people, 27.27%
  9. Spinal Osteoarthritis (joint cartilage loss in spine): 9 people, 27.27%
  10. Arthritis (form of joint disorder that involves inflammation of one or more joints): 8 people, 24.24%

What are the existing conditions these people have? *

  1. Osteoporosis (bones weak and more likely to break): 7 people, 21.21%
  2. Depression: 6 people, 18.18%
  3. High Blood Cholesterol: 6 people, 18.18%
  4. Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 18.18%
  5. High Blood Pressure: 5 people, 15.15%
  6. Vulvovaginal Dryness: 4 people, 12.12%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 9.09%
  8. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 6.06%
  9. Pain: 2 people, 6.06%
  10. Type 1 Diabetes: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and have Retinal disorder?

- Check whether Retinal disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premarin:

Retinal disorder treatments and more:

How severe was Retinal disorder and when was it recovered:

Expand to all the drugs that have ingredients of estrogens, conjugated:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Retinal disorder:

Browse all the conditions that are associated with Retinal disorder:


How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated (the active ingredients of Premarin) and Premarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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