Premphase 14/14 and Insomnia exacerbated - a phase IV clinical study of FDA data

Summary:

Insomnia exacerbated is reported as a side effect among people who take Premphase 14/14 (estrogens, conjugated; medroxyprogesterone acetate), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Albuterol, and have Bronchitis.

The phase IV clinical study analyzes which people have Insomnia exacerbated when taking Premphase 14/14. It is created by eHealthMe based on reports of 1,110 people who have side effects when taking Premphase 14/14 from the FDA, and is updated regularly.

What is Premphase 14/14?

Premphase 14/14 has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 1,114 Premphase 14/14 users. Check the latest studies of Premphase 14/14.

What is Insomnia exacerbated?

Insomnia exacerbated (severe sleeplessness) is found to be associated with 2,651 drugs and 974 conditions by eHealthMe. Check the latest studies of Insomnia exacerbated.

On Jul, 14, 2026

1,110 people reported to have side effects when taking Premphase 14/14.
Among them, 11 people (0.99%) have Insomnia exacerbated.

Could Premphase 14/14 cause Insomnia exacerbated?

Among these 11 people:

How long have people been on Premphase 14/14 when they have Insomnia exacerbated? *

What is the gender of people who have Insomnia exacerbated when taking Premphase 14/14? *

female: 100 %
male: 0.0 %

What is the age of people who have Insomnia exacerbated when taking Premphase 14/14? *

What are other drugs people take besides Premphase 14/14? *

What are other side effects people have besides Insomnia exacerbated? *

Hyperhidrosis (abnormally increased sweating): 4 people, 36.36%
Nausea (feeling of having an urge to vomit): 4 people, 36.36%
Stress And Anxiety: 4 people, 36.36%
Depression: 4 people, 36.36%
Pain: 3 people, 27.27%
Weakness: 3 people, 27.27%
Fall: 3 people, 27.27%
Fatigue (feeling of tiredness): 3 people, 27.27%
Menopause (end of monthly cycles in women): 3 people, 27.27%
Confusional State: 2 people, 18.18%

What are the existing conditions these people have? *

Quit Smoking: 2 people, 18.18%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 18.18%
Thrombophlebitis Superficial (swelling (inflammation) of a superficial vein caused by a blood clot): 1 person, 9.09%
Stress And Anxiety: 1 person, 9.09%
Sleep Disorder: 1 person, 9.09%
Seasonal Allergy (allergic condition due to certain season): 1 person, 9.09%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 9.09%
Migraine (headache): 1 person, 9.09%
Hepatitis C: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Premphase 14/14 and have Insomnia exacerbated?

- Check whether Insomnia exacerbated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premphase 14/14:

Premphase 14/14 (1,114 reports)

Insomnia exacerbated treatments and more:

Insomnia exacerbated (337 reports)

How severe was Insomnia exacerbated and when was it recovered:

Insomnia exacerbated in Premphase 14/14

Expand to all the drugs that have ingredients of estrogens, conjugated; medroxyprogesterone acetate:

Insomnia exacerbated and drugs with ingredients of estrogens, conjugated; medroxyprogesterone acetate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premphase 14/14:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia exacerbated:

Insomnia exacerbated (2,651 drugs)

Browse all the conditions that are associated with Insomnia exacerbated:

Insomnia exacerbated (974 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated; medroxyprogesterone acetate (the active ingredients of Premphase 14/14) and Premphase 14/14 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.