Premphase and Chronic obstructive pulmonary disease - a phase IV clinical study of FDA data

Summary:

Chronic obstructive pulmonary disease is reported as a side effect among people who take Premphase (estrogens, conjugated; medroxyprogesterone acetate), especially for people who are female, 40-49 old, also take Nexium, and have Metastases to bone.

The phase IV clinical study analyzes which people have Chronic obstructive pulmonary disease when taking Premphase. It is created by eHealthMe based on reports of 2,248 people who have side effects when taking Premphase from the FDA, and is updated regularly.

What is Premphase?

Premphase has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 2,262 Premphase users. Check the latest studies of Premphase.

What is Chronic obstructive pulmonary disease?

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe) is found to be associated with 1,800 drugs and 2,209 conditions by eHealthMe. Check the latest studies of Chronic obstructive pulmonary disease.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

2,248 people reported to have side effects when taking Premphase.
Among them, 18 people (0.8%) have Chronic obstructive pulmonary disease.

Could Premphase cause Chronic obstructive pulmonary disease?

Among these 18 people:

What is the gender of people who have Chronic obstructive pulmonary disease when taking Premphase? *

female: 100 %
male: 0.0 %

What is the age of people who have Chronic obstructive pulmonary disease when taking Premphase? *

What are other drugs people take besides Premphase? *

What are other side effects people have besides Chronic obstructive pulmonary disease? *

Chest Pain: 12 people, 66.67%
Depression: 12 people, 66.67%
Pain In Jaw: 11 people, 61.11%
Pain: 11 people, 61.11%
Osteoporosis (bones weak and more likely to break): 11 people, 61.11%
Stress And Anxiety: 11 people, 61.11%
Glaucoma (increased fluid pressure in the eye with vision loss): 11 people, 61.11%
Weakness: 10 people, 55.56%
Dyspnea (difficult or laboured breathing): 10 people, 55.56%
Pericardial Effusion (fluid around the heart): 10 people, 55.56%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 7 people, 38.89%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 22.22%
Osteoporosis (bones weak and more likely to break): 2 people, 11.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.56%
Migraine (headache): 1 person, 5.56%
Menopause (end of monthly cycles in women): 1 person, 5.56%
Indigestion: 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%
Headache (pain in head): 1 person, 5.56%
Dizziness: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Premphase and have Chronic obstructive pulmonary disease?

- Check whether Chronic obstructive pulmonary disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premphase:

Premphase (2,262 reports)

Chronic obstructive pulmonary disease treatments and more:

Chronic obstructive pulmonary disease (198,253 reports)

How severe was Chronic obstructive pulmonary disease and when was it recovered:

Chronic obstructive pulmonary disease in Premphase

Expand to all the drugs that have ingredients of estrogens, conjugated; medroxyprogesterone acetate:

Chronic obstructive pulmonary disease and drugs with ingredients of estrogens, conjugated; medroxyprogesterone acetate (195 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premphase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chronic obstructive pulmonary disease:

Chronic obstructive pulmonary disease (1,800 drugs)

Browse all the conditions that are associated with Chronic obstructive pulmonary disease:

Chronic obstructive pulmonary disease (2,209 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated; medroxyprogesterone acetate (the active ingredients of Premphase) and Premphase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.