Premphase and Fall - a phase IV clinical study of FDA data

Summary:

Fall is reported as a side effect among people who take Premphase (estrogens, conjugated; medroxyprogesterone acetate), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Premarin, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Fall when taking Premphase. It is created by eHealthMe based on reports of 2,248 people who have side effects when taking Premphase from the FDA, and is updated regularly.

What is Premphase?

Premphase has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 2,262 Premphase users. Check the latest studies of Premphase.

What is Fall?

Fall is found to be associated with 3,288 drugs and 3,751 conditions by eHealthMe. Check the latest studies of Fall.

On Nov, 25, 2025

2,248 people reported to have side effects when taking Premphase.
Among them, 34 people (1.51%) have Fall.

Among these 34 people:

How long have people been on Premphase when they have Fall? *

What is the gender of people who have Fall when taking Premphase? *

female: 100 %
male: 0.0 %

What is the age of people who have Fall when taking Premphase? *

What are other drugs people take besides Premphase? *

What are other side effects people have besides Fall? *

Bone Disorder: 20 people, 58.82%
Nausea (feeling of having an urge to vomit): 15 people, 44.12%
Chest Pain: 15 people, 44.12%
Abdominal Pain: 14 people, 41.18%
Weight Decreased: 14 people, 41.18%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 14 people, 41.18%
High Blood Pressure: 14 people, 41.18%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 14 people, 41.18%
Head Injury: 14 people, 41.18%
Stress And Anxiety: 14 people, 41.18%

What are the existing conditions these people have? *

Stress And Anxiety: 13 people, 38.24%
Pain In Jaw: 12 people, 35.29%
Multiple Myeloma (cancer of the plasma cells): 12 people, 35.29%
Osteoporosis (bones weak and more likely to break): 6 people, 17.65%
Menopausal Symptoms: 5 people, 14.71%
Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 11.76%
Quit Smoking: 2 people, 5.88%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 5.88%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Premphase and have Fall?

- Check whether Fall is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premphase:

Premphase (2,262 reports)

Fall treatments and more:

Fall (403,513 reports)

How severe was Fall and when was it recovered:

Fall in Premphase

Expand to all the drugs that have ingredients of estrogens, conjugated; medroxyprogesterone acetate:

Fall and drugs with ingredients of estrogens, conjugated; medroxyprogesterone acetate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premphase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fall:

Fall (3,288 drugs)

Browse all the conditions that are associated with Fall:

Fall (3,751 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated; medroxyprogesterone acetate (the active ingredients of Premphase) and Premphase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.