Premphase and Urinary incontinence - a phase IV clinical study of FDA data

Summary:

Urinary incontinence is reported as a side effect among people who take Premphase (estrogens, conjugated; medroxyprogesterone acetate), especially for people who are female, 60+ old, also take Effexor, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Urinary incontinence when taking Premphase. It is created by eHealthMe based on reports of 2,248 people who have side effects when taking Premphase from the FDA, and is updated regularly.

What is Premphase?

Premphase has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 2,262 Premphase users. Check the latest studies of Premphase.

What is Urinary incontinence?

Urinary incontinence (inability to control the flow of urine and involuntary urination) is found to be associated with 1,638 drugs and 2,517 conditions by eHealthMe. Check the latest studies of Urinary incontinence.

On Jul, 12, 2026

2,248 people reported to have side effects when taking Premphase.
Among them, 20 people (0.89%) have Urinary incontinence.

Could Premphase cause Urinary incontinence?

Among these 20 people:

What is the gender of people who have Urinary incontinence when taking Premphase? *

female: 100 %
male: 0.0 %

What is the age of people who have Urinary incontinence when taking Premphase? *

What are other drugs people take besides Premphase? *

What are other side effects people have besides Urinary incontinence? *

Stress And Anxiety: 16 people, 80.00%
Nausea (feeling of having an urge to vomit): 15 people, 75.00%
Diarrhea: 15 people, 75.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 75.00%
Fever: 15 people, 75.00%
Weight Increased: 14 people, 70.00%
Nausea And Vomiting: 14 people, 70.00%
Weight Decreased: 14 people, 70.00%
High Blood Pressure: 14 people, 70.00%
Fall: 14 people, 70.00%

What are the existing conditions these people have? *

Pain In Jaw: 13 people, 65.00%
Multiple Myeloma (cancer of the plasma cells): 13 people, 65.00%
Stress And Anxiety: 13 people, 65.00%
Pain: 2 people, 10.00%
Thyroid Diseases: 1 person, 5.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.00%
Depression: 1 person, 5.00%
Diabetes: 1 person, 5.00%
Feeling Jittery: 1 person, 5.00%
Metastases To Bone (cancer spreads to bone): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Premphase and have Urinary incontinence?

- Check whether Urinary incontinence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premphase:

Premphase (2,262 reports)

Urinary incontinence treatments and more:

Urinary incontinence (50,139 reports)

How severe was Urinary incontinence and when was it recovered:

Urinary incontinence in Premphase

Expand to all the drugs that have ingredients of estrogens, conjugated; medroxyprogesterone acetate:

Urinary incontinence and drugs with ingredients of estrogens, conjugated; medroxyprogesterone acetate (137 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premphase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Urinary incontinence:

Urinary incontinence (1,638 drugs)

Browse all the conditions that are associated with Urinary incontinence:

Urinary incontinence (2,517 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated; medroxyprogesterone acetate (the active ingredients of Premphase) and Premphase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.