Premphase and Weight decreased - a phase IV clinical study of FDA data

Summary:

Weight decreased is reported as a side effect among people who take Premphase (estrogens, conjugated; medroxyprogesterone acetate), especially for people who are female, 60+ old, also take Nexium, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Weight decreased when taking Premphase. It is created by eHealthMe based on reports of 2,248 people who have side effects when taking Premphase from the FDA, and is updated regularly.

What is Premphase?

Premphase has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. eHealthMe is studying from 2,262 Premphase users. Check the latest studies of Premphase.

What is Weight decreased?

Weight decreased is found to be associated with 3,377 drugs and 4,759 conditions by eHealthMe. Check the latest studies of Weight decreased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

2,248 people reported to have side effects when taking Premphase.
Among them, 53 people (2.36%) have Weight decreased.

Among these 53 people:

What is the gender of people who have Weight decreased when taking Premphase? *

female: 100 %
male: 0.0 %

What is the age of people who have Weight decreased when taking Premphase? *

What are other drugs people take besides Premphase? *

What are other side effects people have besides Weight decreased? *

Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 33 people, 62.26%
Stress And Anxiety: 31 people, 58.49%
Gastric Ulcer (stomach ulcer): 24 people, 45.28%
Insomnia (sleeplessness): 22 people, 41.51%
Fever: 21 people, 39.62%
Diarrhea: 21 people, 39.62%
Abdominal Pain: 21 people, 39.62%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 20 people, 37.74%
Nausea (feeling of having an urge to vomit): 20 people, 37.74%
Dental Caries: 20 people, 37.74%

What are the existing conditions these people have? *

Stress And Anxiety: 17 people, 32.08%
Menopause (end of monthly cycles in women): 13 people, 24.53%
Pain In Jaw: 13 people, 24.53%
Multiple Myeloma (cancer of the plasma cells): 13 people, 24.53%
Metastases To Bone (cancer spreads to bone): 7 people, 13.21%
Sleep Disorder: 5 people, 9.43%
Cardiac Disorder: 3 people, 5.66%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 5.66%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.66%
Depression: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

Do you take Premphase and have Weight decreased?

- Check whether Weight decreased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Premphase:

Premphase (2,262 reports)

Weight decreased treatments and more:

Weight decreased (364,522 reports)

How severe was Weight decreased and when was it recovered:

Weight decreased in Premphase

Expand to all the drugs that have ingredients of estrogens, conjugated; medroxyprogesterone acetate:

Weight decreased and drugs with ingredients of estrogens, conjugated; medroxyprogesterone acetate (434 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Premphase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight decreased:

Weight decreased (3,377 drugs)

Browse all the conditions that are associated with Weight decreased:

Weight decreased (4,759 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated; medroxyprogesterone acetate (the active ingredients of Premphase) and Premphase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.