Prempro and Menopausal symptoms - a phase IV clinical study of FDA data

Summary:

Menopausal symptoms is reported as a side effect among people who take Prempro (estrogens, conjugated; medroxyprogesterone acetate), especially for people who are 60+ old, have been taking the drug for 5 - 10 years also take Fosamax, and have Osteoporosis.

The phase IV clinical study analyzes which people have Menopausal symptoms when taking Prempro. It is created by eHealthMe based on reports of 42,607 people who have side effects when taking Prempro from the FDA, and is updated regularly.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

What is Menopausal symptoms?

Menopausal symptoms is found to be associated with 318 drugs and 440 conditions by eHealthMe. Check the latest studies of Menopausal symptoms.

On Jul, 13, 2026

42,607 people reported to have side effects when taking Prempro.
Among them, 40 people (0.09%) have Menopausal symptoms.

Could Prempro cause Menopausal symptoms?

Among these 40 people:

How long have people been on Prempro when they have Menopausal symptoms? *

What is the age of people who have Menopausal symptoms when taking Prempro? *

What are other drugs people take besides Prempro? *

Fosamax: 9 people, 22.50%
Calcium: 8 people, 20.00%
Vitamin E: 8 people, 20.00%
Vitamin C: 8 people, 20.00%
Vitamin B: 8 people, 20.00%
Magnesium: 8 people, 20.00%
Omega-3 Marine Triglycerides: 7 people, 17.50%
Rosuvastatin Calcium: 7 people, 17.50%
Allegra: 7 people, 17.50%
Glucosamine: 7 people, 17.50%

What are other side effects people have besides Menopausal symptoms? *

Fatigue (feeling of tiredness): 20 people, 50.00%
Depression: 20 people, 50.00%
Joint Pain: 18 people, 45.00%
Stress And Anxiety: 13 people, 32.50%
Fall: 12 people, 30.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 12 people, 30.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 11 people, 27.50%
Dizziness: 10 people, 25.00%
Night Sweats (sweating in night): 10 people, 25.00%
Bone Pain: 9 people, 22.50%

What are the existing conditions these people have? *

Bone Disorder: 9 people, 22.50%
Depression: 9 people, 22.50%
Osteoporosis (bones weak and more likely to break): 9 people, 22.50%
Hormone Level Abnormal: 5 people, 12.50%
High Blood Pressure: 3 people, 7.50%
Glaucoma (increased fluid pressure in the eye with vision loss): 2 people, 5.00%
High Blood Cholesterol: 2 people, 5.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 2.50%
Asthma: 1 person, 2.50%
Enlarged Prostate: 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Prempro and have Menopausal symptoms?

- Check whether Menopausal symptoms is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prempro:

Prempro (42,950 reports)

Menopausal symptoms treatments and more:

Menopausal symptoms (11,826 reports)

How severe was Menopausal symptoms and when was it recovered:

Menopausal symptoms in Prempro

Expand to all the drugs that have ingredients of estrogens, conjugated; medroxyprogesterone acetate:

Menopausal symptoms and drugs with ingredients of estrogens, conjugated; medroxyprogesterone acetate

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prempro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Menopausal symptoms:

Menopausal symptoms (318 drugs)

Browse all the conditions that are associated with Menopausal symptoms:

Menopausal symptoms (440 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated; medroxyprogesterone acetate (the active ingredients of Prempro) and Prempro (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.