Prilosec and Diaphragmatic hernia - a phase IV clinical study of FDA data

Summary:

Diaphragmatic hernia is reported as a side effect among people who take Prilosec (omeprazole), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vioxx, and have High blood pressure.

The phase IV clinical study analyzes which people have Diaphragmatic hernia when taking Prilosec. It is created by eHealthMe based on reports of 171,578 people who have side effects when taking Prilosec from the FDA, and is updated regularly.

What is Prilosec?

Prilosec has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 175,285 Prilosec users. Check the latest studies of Prilosec.

What is Diaphragmatic hernia?

Diaphragmatic hernia (defect or hole in the diaphragm that allows the abdominal contents to move into the chest cavity) is found to be associated with 192 drugs and 219 conditions by eHealthMe. Check the latest studies of Diaphragmatic hernia.

On Jul, 15, 2026

171,578 people reported to have side effects when taking Prilosec.
Among them, 29 people (0.02%) have Diaphragmatic hernia.

Could Prilosec cause Diaphragmatic hernia?

Among these 29 people:

How long have people been on Prilosec when they have Diaphragmatic hernia? *

What is the gender of people who have Diaphragmatic hernia when taking Prilosec? *

female: 56 %
male: 44 %

What is the age of people who have Diaphragmatic hernia when taking Prilosec? *

What are other drugs people take besides Prilosec? *

What are other side effects people have besides Diaphragmatic hernia? *

Chest Pain: 12 people, 41.38%
Headache (pain in head): 10 people, 34.48%
Hypotension (abnormally low blood pressure): 9 people, 31.03%
High Blood Pressure: 9 people, 31.03%
High Blood Cholesterol: 9 people, 31.03%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 9 people, 31.03%
Weakness: 8 people, 27.59%
Stable Angina (a constant chest pain): 8 people, 27.59%
Heart Attack: 8 people, 27.59%
Nausea And Vomiting: 8 people, 27.59%

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 20.69%
Depression: 4 people, 13.79%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 13.79%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 10.34%
Multiple Myeloma (cancer of the plasma cells): 2 people, 6.90%
Metastases To Bone (cancer spreads to bone): 2 people, 6.90%
High Blood Cholesterol: 2 people, 6.90%
Breast Cancer: 1 person, 3.45%
Breast Cancer Metastatic: 1 person, 3.45%
Cardiomyopathy (weakening of the heart muscle): 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Prilosec and have Diaphragmatic hernia?

- Check whether Diaphragmatic hernia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prilosec:

Prilosec (175,285 reports)

Browse all side effects of Prilosec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diaphragmatic hernia:

Diaphragmatic hernia (192 drugs)

Browse all the conditions that are associated with Diaphragmatic hernia:

Diaphragmatic hernia (219 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on omeprazole (the active ingredients of Prilosec) and Prilosec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.