Prilosec and Haemolysis - a phase IV clinical study of FDA data

Summary:

Haemolysis is reported as a side effect among people who take Prilosec (omeprazole), especially for people who are female, 60+ old, also take Soliris, and have Paroxysmal nocturnal haemoglobinuria.

The phase IV clinical study analyzes which people have Haemolysis when taking Prilosec. It is created by eHealthMe based on reports of 171,578 people who have side effects when taking Prilosec from the FDA, and is updated regularly.

What is Prilosec?

Prilosec has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 175,286 Prilosec users. Check the latest studies of Prilosec.

What is Haemolysis?

Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid) is found to be associated with 610 drugs and 838 conditions by eHealthMe. Check the latest studies of Haemolysis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

171,578 people reported to have side effects when taking Prilosec.
Among them, 65 people (0.04%) have Haemolysis.

Among these 65 people:

What is the gender of people who have Haemolysis when taking Prilosec? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Haemolysis when taking Prilosec? *

What are other drugs people take besides Prilosec? *

What are other side effects people have besides Haemolysis? *

Anaemia (lack of blood): 17 people, 26.15%
Haemoglobin Decreased: 13 people, 20.00%
Blood Lactate Dehydrogenase Increased: 13 people, 20.00%
Fatigue (feeling of tiredness): 12 people, 18.46%
Thrombocytopenia (decrease of platelets in blood): 12 people, 18.46%
Blood Bilirubin Increased: 11 people, 16.92%
Fever: 11 people, 16.92%
Chest Pain: 11 people, 16.92%
Abdominal Pain: 11 people, 16.92%
Back Pain: 10 people, 15.38%

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 17 people, 26.15%
Pulmonary Hypertension Primary (increase in blood pressure in the lung artery with no cause): 4 people, 6.15%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 6.15%
Pain: 4 people, 6.15%
Oedema Peripheral (superficial swelling): 4 people, 6.15%
Nausea (feeling of having an urge to vomit): 4 people, 6.15%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3 people, 4.62%
Cellulitis (infection under the skin): 3 people, 4.62%
Fungal Endocarditis (fungal infection of the inner layer of the heart): 3 people, 4.62%
Oesophageal Candidiasis (fungal infection of oesophagus): 3 people, 4.62%

* Approximation only. Some reports may have incomplete information.

Do you take Prilosec and have Haemolysis?

- Check whether Haemolysis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prilosec:

Prilosec (175,286 reports)

Haemolysis treatments and more:

Haemolysis (9,155 reports)

Browse all side effects of Prilosec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Haemolysis:

Haemolysis (610 drugs)

Browse all the conditions that are associated with Haemolysis:

Haemolysis (838 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on omeprazole (the active ingredients of Prilosec) and Prilosec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.