Primaquine and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Primaquine (primaquine phosphate), especially for people who are male, 40-49 old, have been taking the drug for 1 - 6 months also take Lariam, and have Malaria.

The phase IV clinical study analyzes which people have Depression when taking Primaquine. It is created by eHealthMe based on reports of 474 people who have side effects when taking Primaquine from the FDA, and is updated regularly.

What is Primaquine?

Primaquine has active ingredients of primaquine phosphate. eHealthMe is studying from 483 Primaquine users. Check the latest studies of Primaquine.

What is Depression?

Depression is found to be associated with 3,167 drugs and 4,127 conditions by eHealthMe. Check the latest studies of Depression.

On Aug, 08, 2026

474 people reported to have side effects when taking Primaquine.
Among them, 32 people (6.75%) have Depression.

Among these 32 people:

How long have people been on Primaquine when they have Depression? *

What is the gender of people who have Depression when taking Primaquine? *

female: 9.38 %
male: 90.62 %

What is the age of people who have Depression when taking Primaquine? *

What are other drugs people take besides Primaquine? *

What are other side effects people have besides Depression? *

Stress And Anxiety: 27 people, 84.38%
Dizziness: 26 people, 81.25%
Mood Swings (an extreme or rapid change in mood): 25 people, 78.12%
Insomnia (sleeplessness): 25 people, 78.12%
Disturbance In Attention: 25 people, 78.12%
Memory Loss: 25 people, 78.12%
Aggression: 25 people, 78.12%
Agitation (state of anxiety or nervous excitement): 25 people, 78.12%
Head Injury: 24 people, 75.00%
Headache (pain in head): 24 people, 75.00%

What are the existing conditions these people have? *

Malaria (a parasitic disease due to mosquito bite): 21 people, 65.62%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 2 people, 6.25%
Pneumonia Pneumococcal (pneumococcal pneumonia is a common but serious infection and inflammation of the lungs): 2 people, 6.25%
Pneumonia Bacterial (pneumonia associated with bacterial infection): 2 people, 6.25%
Pneumonia: 2 people, 6.25%
Hypokalemia (low potassium): 2 people, 6.25%
Hiv Infection: 2 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.25%
Fungal Infection: 2 people, 6.25%
Cytomegalovirus Infection: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Primaquine and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Primaquine:

Primaquine (483 reports)

Depression treatments and more:

Depression (652,152 reports)

Browse all side effects of Primaquine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,167 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,127 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on primaquine phosphate (the active ingredients of Primaquine) and Primaquine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.