Primidone and Mental impairment - a phase IV clinical study of FDA data

Summary:

Mental impairment is reported as a side effect among people who take Primidone (primidone), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Depakote, and have Restless leg syndrome.

The phase IV clinical study analyzes which people have Mental impairment when taking Primidone. It is created by eHealthMe based on reports of 10,125 people who have side effects when taking Primidone from the FDA, and is updated regularly.

What is Primidone?

Primidone has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 10,474 Primidone users. Check the latest studies of Primidone.

What is Mental impairment?

Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition) is found to be associated with 1,336 drugs and 1,316 conditions by eHealthMe. Check the latest studies of Mental impairment.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

10,125 people reported to have side effects when taking Primidone.
Among them, 32 people (0.32%) have Mental impairment.

Could Primidone cause Mental impairment?

Among these 32 people:

How long have people been on Primidone when they have Mental impairment? *

What is the gender of people who have Mental impairment when taking Primidone? *

female: 39.29 %
male: 60.71 %

What is the age of people who have Mental impairment when taking Primidone? *

What are other drugs people take besides Primidone? *

Depakote: 7 people, 21.88%
Lithium Carbonate: 6 people, 18.75%
Atenolol: 5 people, 15.62%
Levetiracetam: 4 people, 12.50%
Phenytoin Sodium: 4 people, 12.50%
Progesterone: 4 people, 12.50%
Gabitril: 4 people, 12.50%
Enalapril Maleate: 4 people, 12.50%
Sertraline Hydrochloride: 4 people, 12.50%
Loratadine: 4 people, 12.50%

What are other side effects people have besides Mental impairment? *

Weakness: 9 people, 28.12%
Speech Impairment (Adult) (inability to speak (adult)): 7 people, 21.88%
Memory Loss: 6 people, 18.75%
Fatigue (feeling of tiredness): 6 people, 18.75%
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain): 5 people, 15.62%
Electroencephalogram Abnormal: 5 people, 15.62%
Crying: 5 people, 15.62%
Nausea (feeling of having an urge to vomit): 5 people, 15.62%
Confusional State: 5 people, 15.62%
Drowsiness: 5 people, 15.62%

What are the existing conditions these people have? *

Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 12.50%
Vitamin D Decreased: 3 people, 9.38%
Bartter's Syndrome (inherited defect in the thick ascending limb of the loop of henle): 3 people, 9.38%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 3 people, 9.38%
Adverse Drug Reaction: 3 people, 9.38%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 9.38%
Back Pain: 2 people, 6.25%
Depression: 2 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 3.12%
Alcoholism (problems with alcohol): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Primidone and have Mental impairment?

- Check whether Mental impairment is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Primidone:

Primidone (10,474 reports)

Browse all side effects of Primidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental impairment:

Mental impairment (1,336 drugs)

Browse all the conditions that are associated with Mental impairment:

Mental impairment (1,316 conditions)

Related publications that referenced our studies

Momtaz YA, Hamid TA, Ibrahim R, "The impact of mild cognitive impairment on sexual activity", American Journal of Alzheimer's Disease & Other Dementias?, 2013 Jan .
Momtaz YA, Hamid TA, Ibrahim R, "The impact of mild cognitive impairment on sexual activity", American Journal of Alzheimer's Disease & Other Dementias?, 2013 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on primidone (the active ingredients of Primidone) and Primidone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.