Primrose and Hot flush - a phase IV clinical study of FDA data

Summary:

Hot flush is reported as a side effect among people who take Primrose (evening primrose oil), especially for people who are 60+ old, also take Fish Oil, and have Reflux laryngitis.

The phase IV clinical study analyzes which people have Hot flush when taking Primrose. It is created by eHealthMe based on reports of 2,030 people who have side effects when taking Primrose from the FDA, and is updated regularly.

What is Primrose?

Primrose has active ingredients of evening primrose oil. It is often used in hair loss. eHealthMe is studying from 2,314 Primrose users. Check the latest studies of Primrose.

What is Hot flush?

Hot flush (sudden feelings of heat) is found to be associated with 1,772 drugs and 2,347 conditions by eHealthMe. Check the latest studies of Hot flush.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

2,030 people reported to have side effects when taking Primrose.
Among them, 57 people (2.81%) have Hot flush.

Among these 57 people:

What is the age of people who have Hot flush when taking Primrose? *

What are other drugs people take besides Primrose? *

What are other side effects people have besides Hot flush? *

Insomnia (sleeplessness): 17 people, 29.82%
Bone Pain: 12 people, 21.05%
Joint Pain: 10 people, 17.54%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 10 people, 17.54%
Abdominal Pain Upper: 9 people, 15.79%
Fatigue (feeling of tiredness): 9 people, 15.79%
Night Sweats (sweating in night): 9 people, 15.79%
Nausea (feeling of having an urge to vomit): 9 people, 15.79%
Headache (pain in head): 8 people, 14.04%
Abdominal Distension: 8 people, 14.04%

What are the existing conditions these people have? *

Reflux Laryngitis (voice disorder caused by backflow of stomach fluids to the throat and voice box area): 8 people, 14.04%
Multiple Myeloma (cancer of the plasma cells): 7 people, 12.28%
Muscle Spasms (muscle contraction): 6 people, 10.53%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 10.53%
Prostate Cancer: 6 people, 10.53%
Breast Cancer Female: 5 people, 8.77%
High Blood Cholesterol: 4 people, 7.02%
Breast Cancer: 4 people, 7.02%
Immunodeficiency Common Variable: 4 people, 7.02%
Menopause (end of monthly cycles in women): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Primrose and have Hot flush?

- Check whether Hot flush is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Primrose:

Primrose (2,314 reports)

Hot flush treatments and more:

Hot flush (91,208 reports)

Browse all side effects of Primrose:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hot flush:

Hot flush (1,772 drugs)

Browse all the conditions that are associated with Hot flush:

Hot flush (2,347 conditions)

Related publications that referenced our studies

Min IS, Lee JY, Jung TS, Kang NK, Park BB, Kim BK, "Development of a Complete Atrioventricular Block Associated with Intake of Evening Primrose Oil", The Korean Journal of Medicine, 2016 May .
Min IS, Lee JY, Jung TS, Kang NK, Park BB, Kim BK, "Development of a Complete Atrioventricular Block Associated with Intake of Evening Primrose Oil", The Korean Journal of Medicine, 2016 May .

How the study uses the data?

The study uses data from the FDA. It is based on evening primrose oil (the active ingredients of Primrose) and Primrose (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.