Prinzide and Insomnia exacerbated - a phase IV clinical study of FDA data

Summary:

Insomnia exacerbated is reported as a side effect among people who take Prinzide (hydrochlorothiazide; lisinopril), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lasix, and have Pain.

The phase IV clinical study analyzes which people have Insomnia exacerbated when taking Prinzide. It is created by eHealthMe based on reports of 2,155 people who have side effects when taking Prinzide from the FDA, and is updated regularly.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

What is Insomnia exacerbated?

Insomnia exacerbated (severe sleeplessness) is found to be associated with 2,564 drugs and 942 conditions by eHealthMe. Check the latest studies of Insomnia exacerbated.

On Dec, 29, 2025

2,155 people reported to have side effects when taking Prinzide.
Among them, 46 people (2.13%) have Insomnia exacerbated.

Could Prinzide cause Insomnia exacerbated?

Among these 46 people:

How long have people been on Prinzide when they have Insomnia exacerbated? *

What is the gender of people who have Insomnia exacerbated when taking Prinzide? *

female: 76.09 %
male: 23.91 %

What is the age of people who have Insomnia exacerbated when taking Prinzide? *

What are other drugs people take besides Prinzide? *

What are other side effects people have besides Insomnia exacerbated? *

Fatigue (feeling of tiredness): 11 people, 23.91%
Stress And Anxiety: 10 people, 21.74%
Weakness: 9 people, 19.57%
Depression: 9 people, 19.57%
Dizziness: 9 people, 19.57%
Pain: 8 people, 17.39%
Chest Pain: 8 people, 17.39%
Joint Pain: 8 people, 17.39%
Dyspnea (difficult or laboured breathing): 7 people, 15.22%
Nausea (feeling of having an urge to vomit): 7 people, 15.22%

What are the existing conditions these people have? *

Pain: 9 people, 19.57%
Stress And Anxiety: 3 people, 6.52%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 4.35%
Muscle Spasms (muscle contraction): 2 people, 4.35%
Diabetes: 2 people, 4.35%
Type 2 Diabetes: 2 people, 4.35%
Back Pain: 2 people, 4.35%
Depression: 2 people, 4.35%
Quit Smoking: 2 people, 4.35%
High Blood Cholesterol: 2 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Prinzide and have Insomnia exacerbated?

- Check whether Insomnia exacerbated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prinzide:

Prinzide (2,218 reports)

Insomnia exacerbated treatments and more:

Insomnia exacerbated (337 reports)

How severe was Insomnia exacerbated and when was it recovered:

Insomnia exacerbated in Prinzide

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Insomnia exacerbated and drugs with ingredients of hydrochlorothiazide; lisinopril (538 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prinzide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Insomnia exacerbated:

Insomnia exacerbated (2,564 drugs)

Browse all the conditions that are associated with Insomnia exacerbated:

Insomnia exacerbated (942 conditions)

Drugs similar to Prinzide and Insomnia exacerbated :

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Prinzide) and Prinzide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.