Prinzide and Joint swelling - a phase IV clinical study of FDA data

Summary:

Joint swelling is reported as a side effect among people who take Prinzide (hydrochlorothiazide; lisinopril), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aspirin, and have Depression.

The phase IV clinical study analyzes which people have Joint swelling when taking Prinzide. It is created by eHealthMe based on reports of 2,155 people who have side effects when taking Prinzide from the FDA, and is updated regularly.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

What is Joint swelling?

Joint swelling is found to be associated with 2,123 drugs and 2,934 conditions by eHealthMe. Check the latest studies of Joint swelling.

On Jul, 10, 2026

2,155 people reported to have side effects when taking Prinzide.
Among them, 12 people (0.56%) have Joint swelling.

Among these 12 people:

How long have people been on Prinzide when they have Joint swelling? *

What is the gender of people who have Joint swelling when taking Prinzide? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Joint swelling when taking Prinzide? *

What are other drugs people take besides Prinzide? *

What are other side effects people have besides Joint swelling? *

Oedema Peripheral (superficial swelling): 6 people, 50.00%
Pneumonia: 3 people, 25.00%
Joint Pain: 3 people, 25.00%
Dyspnea (difficult or laboured breathing): 2 people, 16.67%
Cellulitis (infection under the skin): 2 people, 16.67%
Pain: 2 people, 16.67%
Cardiac Failure Congestive: 2 people, 16.67%
Discomfort: 2 people, 16.67%
Stress And Anxiety: 2 people, 16.67%
Chest Pain: 2 people, 16.67%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 16.67%
Depression: 2 people, 16.67%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 8.33%
High Blood Cholesterol: 1 person, 8.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 8.33%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 1 person, 8.33%
Diabetes: 1 person, 8.33%
Essential Hypertension (primary hypertension): 1 person, 8.33%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 8.33%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Prinzide and have Joint swelling?

- Check whether Joint swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prinzide:

Prinzide (2,218 reports)

Joint swelling treatments and more:

Joint swelling (143,797 reports)

How severe was Joint swelling and when was it recovered:

Joint swelling in Prinzide

Expand to all the drugs that have ingredients of hydrochlorothiazide; lisinopril:

Joint swelling and drugs with ingredients of hydrochlorothiazide; lisinopril

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prinzide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint swelling:

Joint swelling (2,123 drugs)

Browse all the conditions that are associated with Joint swelling:

Joint swelling (2,934 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril (the active ingredients of Prinzide) and Prinzide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.