Pristiq and Akathisia - a phase IV clinical study of FDA data

Summary:

Akathisia is reported as a side effect among people who take Pristiq (desvenlafaxine succinate), especially for people who are male, 50-59 old, have been taking the drug for 6 - 12 months also take Ativan, and have Insomnia.

The phase IV clinical study analyzes which people have Akathisia when taking Pristiq. It is created by eHealthMe based on reports of 15,699 people who have side effects when taking Pristiq from the FDA, and is updated regularly.

What is Pristiq?

Pristiq has active ingredients of desvenlafaxine succinate. It is often used in depression. eHealthMe is studying from 19,555 Pristiq users. Check the latest studies of Pristiq.

What is Akathisia?

Akathisia (a movement disorder characterized by a feeling of inner restlessness) is found to be associated with 441 drugs and 824 conditions by eHealthMe. Check the latest studies of Akathisia.

On Jul, 26, 2026

15,699 people reported to have side effects when taking Pristiq.
Among them, 31 people (0.2%) have Akathisia.

Among these 31 people:

How long have people been on Pristiq when they have Akathisia? *

What is the gender of people who have Akathisia when taking Pristiq? *

female: 43.33 %
male: 56.67 %

What is the age of people who have Akathisia when taking Pristiq? *

What are other drugs people take besides Pristiq? *

What are other side effects people have besides Akathisia? *

Agitation (state of anxiety or nervous excitement): 14 people, 45.16%
Insomnia (sleeplessness): 9 people, 29.03%
Drug Ineffective: 6 people, 19.35%
Drowsiness: 5 people, 16.13%
Tremor (trembling or shaking movements in one or more parts of your body): 5 people, 16.13%
Fatigue (feeling of tiredness): 4 people, 12.90%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 12.90%
Energy Increased: 4 people, 12.90%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 4 people, 12.90%
Dyskinesia (abnormality or impairment of voluntary movement): 3 people, 9.68%

What are the existing conditions these people have? *

Insomnia (sleeplessness): 3 people, 9.68%
Sleep Apnea Syndrome: 2 people, 6.45%
Erection Problems: 1 person, 3.23%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 3.23%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 3.23%
Bipolar Disorder (mood disorder): 1 person, 3.23%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 1 person, 3.23%
Bladder Outlet Obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded): 1 person, 3.23%
Cardiac Disorder: 1 person, 3.23%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Pristiq and have Akathisia?

- Check whether Akathisia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pristiq:

Pristiq (19,555 reports)

Akathisia treatments and more:

Akathisia (15,139 reports)

Browse all side effects of Pristiq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Akathisia:

Akathisia (441 drugs)

Browse all the conditions that are associated with Akathisia:

Akathisia (824 conditions)

Related publications that referenced our studies

Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on desvenlafaxine succinate (the active ingredients of Pristiq) and Pristiq (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.