Progesterone and Bone pain - a phase IV clinical study of FDA data

Summary:

Bone pain is reported as a side effect among people who take Progesterone (progesterone), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Vitamin D3, and have Osteoporosis.

The phase IV clinical study analyzes which people have Bone pain when taking Progesterone. It is created by eHealthMe based on reports of 20,008 people who have side effects when taking Progesterone from the FDA, and is updated regularly.

What is Progesterone?

Progesterone has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 21,022 Progesterone users. Check the latest studies of Progesterone.

What is Bone pain?

Bone pain is found to be associated with 1,811 drugs and 1,778 conditions by eHealthMe. Check the latest studies of Bone pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

20,008 people reported to have side effects when taking Progesterone.
Among them, 84 people (0.42%) have Bone pain.

Among these 84 people:

How long have people been on Progesterone when they have Bone pain? *

What is the gender of people who have Bone pain when taking Progesterone? *

female: 98.67 %
male: 1.33 %

What is the age of people who have Bone pain when taking Progesterone? *

What are other drugs people take besides Progesterone? *

What are other side effects people have besides Bone pain? *

Joint Pain: 27 people, 32.14%
Muscle Aches (muscle pain): 21 people, 25.00%
Headache (pain in head): 20 people, 23.81%
Pain In Extremity: 19 people, 22.62%
Fatigue (feeling of tiredness): 19 people, 22.62%
Pain: 17 people, 20.24%
Nausea (feeling of having an urge to vomit): 14 people, 16.67%
Feeling Abnormal: 13 people, 15.48%
Diarrhea: 13 people, 15.48%
Weakness: 13 people, 15.48%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 12 people, 14.29%
Migraine (headache): 9 people, 10.71%
Immunodeficiency Common Variable: 8 people, 9.52%
Pain: 7 people, 8.33%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 5.95%
Depression: 5 people, 5.95%
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 5 people, 5.95%
Nausea (feeling of having an urge to vomit): 5 people, 5.95%
High Blood Pressure: 4 people, 4.76%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 4 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Progesterone and have Bone pain?

- Check whether Bone pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Progesterone:

Progesterone (21,022 reports)

Bone pain treatments and more:

Bone pain (76,561 reports)

Browse all side effects of Progesterone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone pain:

Bone pain (1,811 drugs)

Browse all the conditions that are associated with Bone pain:

Bone pain (1,778 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on progesterone (the active ingredients of Progesterone) and Progesterone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.