Progesterone and Hypospadias - a phase IV clinical study of FDA data

Summary:

Hypospadias is reported as a side effect among people who take Progesterone (progesterone), especially for people who are 0-1 old, have been taking the drug for 1 - 6 months also take Folate, and have Hepatitis b.

The phase IV clinical study analyzes which people have Hypospadias when taking Progesterone. It is created by eHealthMe based on reports of 20,008 people who have side effects when taking Progesterone from the FDA, and is updated regularly.

What is Progesterone?

Progesterone has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 21,022 Progesterone users. Check the latest studies of Progesterone.

What is Hypospadias?

Hypospadias (an abnormal condition in males in which the urethra opens on the under surface of the penis) is found to be associated with 138 drugs and 59 conditions by eHealthMe. Check the latest studies of Hypospadias.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

20,008 people reported to have side effects when taking Progesterone.
Among them, 27 people (0.13%) have Hypospadias.

Among these 27 people:

How long have people been on Progesterone when they have Hypospadias? *

What is the age of people who have Hypospadias when taking Progesterone? *

What are other drugs people take besides Progesterone? *

What are other side effects people have besides Hypospadias? *

Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 12 people, 44.44%
Genitalia External Ambiguous (external genitals don't appear to be clearly either male or female): 6 people, 22.22%
Hydrocele: 5 people, 18.52%
Small For Dates Baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age): 5 people, 18.52%
Enlarged Clitoris: 4 people, 14.81%
Mosaicism (presence of two or more populations of cells with different genotypes in one individual): 4 people, 14.81%
Maternal Exposure During Pregnancy (use of substance during pregnancy): 4 people, 14.81%
Labia Enlarged (large labia): 2 people, 7.41%
Apgar Score Low: 2 people, 7.41%
Brain Hypoxia (reduced supply of oxygen to the brain): 2 people, 7.41%

What are the existing conditions these people have? *

Hepatitis B: 6 people, 22.22%
Labor Induction: 4 people, 14.81%
Urinary Tract Infection: 4 people, 14.81%
High Blood Pressure: 3 people, 11.11%
Sinusitis (inflammation of sinus): 3 people, 11.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 11.11%
Hypersensitivity: 2 people, 7.41%
Cardiac Disorder: 1 person, 3.70%
Abortion Threatened (abortion with vaginal bleeding): 1 person, 3.70%
Anaemia (lack of blood): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Progesterone and have Hypospadias?

- Check whether Hypospadias is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Progesterone:

Progesterone (21,022 reports)

Hypospadias treatments and more:

Hypospadias (2,613 reports)

Browse all side effects of Progesterone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypospadias:

Hypospadias (138 drugs)

Browse all the conditions that are associated with Hypospadias:

Hypospadias (59 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on progesterone (the active ingredients of Progesterone) and Progesterone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.