Prograf and Mean cell volume increased - a phase IV clinical study of FDA data

Summary:

Mean cell volume increased is reported as a side effect among people who take Prograf (tacrolimus), especially for people who are male, 60+ old, also take Tacrolimus, and have Prostate infection.

The phase IV clinical study analyzes which people have Mean cell volume increased when taking Prograf. It is created by eHealthMe based on reports of 41,725 people who have side effects when taking Prograf from the FDA, and is updated regularly.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

What is Mean cell volume increased?

Mean cell volume increased (more than normal average red blood cell volume) is found to be associated with 453 drugs and 495 conditions by eHealthMe. Check the latest studies of Mean cell volume increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

41,725 people reported to have side effects when taking Prograf.
Among them, 66 people (0.16%) have Mean cell volume increased.

Could Prograf cause Mean cell volume increased?

Among these 66 people:

What is the gender of people who have Mean cell volume increased when taking Prograf? *

female: 3.28 %
male: 96.72 %

What is the age of people who have Mean cell volume increased when taking Prograf? *

What are other drugs people take besides Prograf? *

Tacrolimus: 52 people, 78.79%
Sodium Bicarbonate: 49 people, 74.24%
Aranesp: 49 people, 74.24%
Carvedilol: 49 people, 74.24%
Torsemide: 49 people, 74.24%
Furosemide: 49 people, 74.24%
Candesartan Cilexetil: 48 people, 72.73%
Myfortic: 48 people, 72.73%
Hygroton: 47 people, 71.21%
Tamsulosin Hydrochloride: 47 people, 71.21%

What are other side effects people have besides Mean cell volume increased? *

Haemoglobin Decreased: 52 people, 78.79%
Red Blood Cell Count Decreased: 51 people, 77.27%
Oedema Peripheral (superficial swelling): 49 people, 74.24%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 49 people, 74.24%
Presyncope: 49 people, 74.24%
Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 49 people, 74.24%
Hepatomegaly (abnormal enlargement of the liver): 49 people, 74.24%
Bradycardia (abnormally slow heart action): 49 people, 74.24%
C-Reactive Protein Increased: 49 people, 74.24%
Carotid Arteriosclerosis (plaque deposition in artery): 49 people, 74.24%

What are the existing conditions these people have? *

Prostate Infection: 42 people, 63.64%
High Blood Cholesterol: 41 people, 62.12%
Cardiac Disorder: 41 people, 62.12%
Fluid Retention (an abnormal accumulation of fluid in the blood): 41 people, 62.12%
Abdominal Discomfort: 40 people, 60.61%
Blood Pressure Abnormal: 37 people, 56.06%
High Blood Pressure: 16 people, 24.24%
Depression: 13 people, 19.70%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 12 people, 18.18%
Immunodeficiency Disorders: 2 people, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Prograf and have Mean cell volume increased?

- Check whether Mean cell volume increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prograf:

Prograf (42,230 reports)

Browse all side effects of Prograf:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mean cell volume increased:

Mean cell volume increased (453 drugs)

Browse all the conditions that are associated with Mean cell volume increased:

Mean cell volume increased (495 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Prograf) and Prograf (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.